PMID- 28255561
OWN - NLM
STAT- MEDLINE
DCOM- 20170322
LR  - 20181113
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2017
DP  - 2017
TI  - Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis.
PG  - 3073504
LID - 10.1155/2017/3073504 [doi]
LID - 3073504
AB  - Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a 
      chronic and progressive cholestatic liver disease characterized by the presence 
      of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most 
      effective and approved treatment for PBC and leads to a favorable outcome in the 
      vast majority of cases. Although the etiology of PBC has not yet been elucidated, 
      human leukocyte antigen (HLA) class II alleles have been consistently associated 
      with disease onset for decades. Individuals in different geographic regions of 
      the world may have varying susceptibility alleles that reflect indigenous 
      triggering antigens. In this review, we describe the influence of HLA alleles and 
      other gene polymorphisms on PBC along with the results of genome-wide association 
      studies (GWAS) on this disease.
FAU - Joshita, Satoru
AU  - Joshita S
AUID- ORCID: 0000-0002-6364-9654
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
FAU - Umemura, Takeji
AU  - Umemura T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
FAU - Tanaka, Eiji
AU  - Tanaka E
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
FAU - Ota, Masao
AU  - Ota M
AUID- ORCID: 0000-0002-6400-5658
AD  - Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 
      Matsumoto, Nagano 390-8621, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170201
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (HLA Antigens)
RN  - 724L30Y2QR (Ursodeoxycholic Acid)
SB  - IM
MH  - Alleles
MH  - Cholangitis/*genetics/physiopathology
MH  - Disease Susceptibility
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Liver Cirrhosis, Biliary/*genetics/physiopathology
MH  - Polymorphism, Genetic
MH  - Ursodeoxycholic Acid/therapeutic use
PMC - PMC5309396
COIS- The authors declare that they have nothing to disclose regarding funding from 
      industries or conflict of interests with respect to this manuscript.
EDAT- 2017/03/04 06:00
MHDA- 2017/03/23 06:00
PMCR- 2017/02/01
CRDT- 2017/03/04 06:00
PHST- 2016/10/18 00:00 [received]
PHST- 2017/01/12 00:00 [accepted]
PHST- 2017/03/04 06:00 [entrez]
PHST- 2017/03/04 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - 10.1155/2017/3073504 [doi]
PST - ppublish
SO  - J Immunol Res. 2017;2017:3073504. doi: 10.1155/2017/3073504. Epub 2017 Feb 1.