PMID- 28256073
OWN - NLM
STAT- MEDLINE
DCOM- 20170619
LR  - 20181113
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 16
IP  - 2
DP  - 2017 Apr
TI  - Aging impairs dendrite morphogenesis of newborn neurons and is rescued by 7, 
      8-dihydroxyflavone.
PG  - 304-311
LID - 10.1111/acel.12553 [doi]
AB  - All aging individuals will develop some degree of decline in cognitive capacity 
      as time progresses. The molecular and cellular mechanisms leading to age-related 
      cognitive decline are still not fully understood. Through our previous research, 
      we discovered that active neural progenitor cells selectively become more 
      quiescent in response to aging, thus leading to the decline of neurogenesis in 
      the aged hippocampus. Here, we further find that aging impaired dendrite 
      development of newborn neurons. Currently, no effective approach is available to 
      increase neurogenesis or promote dendrite development of newborn neurons in the 
      aging brain. We found that systemically administration of 7, 8-dihydroxyflavone 
      (DHF), a small molecule imitating brain-derived neurotrophic factor (BDNF), 
      significantly enhanced dendrite length in the newborn neurons, while it did not 
      promote survival of immature neurons, in the hippocampus of 12-month-old mice. 
      DHF-promoted dendrite development of newborn neurons in the hippocampus may 
      enhance their function in the aging animal leading to a possible improvement in 
      cognition.
CI  - (c) 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley 
      & Sons Ltd.
FAU - Wang, Xiaoting
AU  - Wang X
AD  - Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research 
      Institute, Indianapolis, IN, 46202, USA.
AD  - Department of Neurological Surgery, Indiana University School of Medicine, 
      Indianapolis, IN, 46202, USA.
FAU - Romine, Jennifer Lynn
AU  - Romine JL
AD  - Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research 
      Institute, Indianapolis, IN, 46202, USA.
AD  - Department of Neurological Surgery, Indiana University School of Medicine, 
      Indianapolis, IN, 46202, USA.
FAU - Gao, Xiang
AU  - Gao X
AD  - Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research 
      Institute, Indianapolis, IN, 46202, USA.
AD  - Department of Neurological Surgery, Indiana University School of Medicine, 
      Indianapolis, IN, 46202, USA.
FAU - Chen, Jinhui
AU  - Chen J
AD  - Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research 
      Institute, Indianapolis, IN, 46202, USA.
AD  - Department of Neurological Surgery, Indiana University School of Medicine, 
      Indianapolis, IN, 46202, USA.
LA  - eng
GR  - R21 NS072631/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (6,7-dihydroxyflavone)
RN  - 0 (Flavones)
SB  - IM
MH  - Aging/drug effects/*pathology
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Count
MH  - Cell Shape/drug effects
MH  - Dendrites/drug effects/*metabolism
MH  - Flavones/*pharmacology
MH  - Hippocampus/drug effects/pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Models, Biological
MH  - Morphogenesis/*drug effects
MH  - Neurogenesis/drug effects
MH  - Survival Analysis
PMC - PMC5334527
OTO - NOTNLM
OT  - aging
OT  - brain-derived neurotrophic factor signaling
OT  - dendritic morphology
EDAT- 2017/03/04 06:00
MHDA- 2017/06/20 06:00
PMCR- 2017/04/01
CRDT- 2017/03/04 06:00
PHST- 2016/10/31 00:00 [accepted]
PHST- 2017/03/04 06:00 [entrez]
PHST- 2017/03/04 06:00 [pubmed]
PHST- 2017/06/20 06:00 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - ACEL12553 [pii]
AID - 10.1111/acel.12553 [doi]
PST - ppublish
SO  - Aging Cell. 2017 Apr;16(2):304-311. doi: 10.1111/acel.12553.