PMID- 2825669
OWN - NLM
STAT- MEDLINE
DCOM- 19871221
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 148
IP  - 2
DP  - 1987 Oct 29
TI  - A biological response modifier, PSK, inhibits human immunodeficiency virus 
      infection in vitro.
PG  - 726-33
AB  - PSK, a biological response modifier (BRM), was studied to determine its 
      anti-viral activity on human immunodeficiency virus (HIV) in vitro. Either a 
      novel infection system using human T-cell lymphotropic virus type I 
      (HTLV-I)-carrying MT-4 cells or a coculture system using MOLT-4 cells and its 
      virus-producing cells MOLT-4/HIVHTLV-IIIB which induces multinucleated giant 
      cells very efficiently was used. PSK almost completely blocked the cytopathic 
      effect such as giant cell formation and HIV-specific antigen expression both in 
      MT-4 cells and MOLT-4 cells at a concentration of 0.4 and 0.8 mg/ml, 
      respectively. Pretreatment of the virus with PSK may specifically interfere with 
      early stages of HIV infection by modifying the viral receptor.
FAU - Tochikura, T S
AU  - Tochikura TS
AD  - Dept. of Virology and Parasitology, Yamaguchi University School of Medicine, 
      Japan.
FAU - Nakashima, H
AU  - Nakashima H
FAU - Hirose, K
AU  - Hirose K
FAU - Yamamoto, N
AU  - Yamamoto N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Antigens, Viral)
RN  - 0 (Antiviral Agents)
RN  - 0 (Proteoglycans)
RN  - 3X48A86C8K (polysaccharide-K)
SB  - IM
MH  - Antigens, Viral/analysis
MH  - Antiviral Agents/*pharmacology
MH  - Cell Line
MH  - Deltaretrovirus/*drug effects/genetics/growth & development
MH  - Fluorescent Antibody Technique
MH  - HIV/*drug effects/genetics/growth & development
MH  - Humans
MH  - Kinetics
MH  - Proteoglycans/*pharmacology
EDAT- 1987/10/29 00:00
MHDA- 1987/10/29 00:01
CRDT- 1987/10/29 00:00
PHST- 1987/10/29 00:00 [pubmed]
PHST- 1987/10/29 00:01 [medline]
PHST- 1987/10/29 00:00 [entrez]
AID - 0006-291X(87)90936-3 [pii]
AID - 10.1016/0006-291x(87)90936-3 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1987 Oct 29;148(2):726-33. doi: 
      10.1016/0006-291x(87)90936-3.