PMID- 28257759
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20181202
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 90
DP  - 2017 Apr
TI  - Blockade of TrkB receptors in the nucleus accumbens prior to heterotypic stress 
      alters corticotropin-releasing hormone (CRH), vesicular glutamate transporter 2 
      (vGluT2) and glucocorticoid receptor (GR) within the mesolimbic pathway.
PG  - 98-112
LID - S0018-506X(16)30323-3 [pii]
LID - 10.1016/j.yhbeh.2017.02.012 [doi]
AB  - Inhibition of stress-induced elevations in brain-derived neurotrophic factor 
      (BDNF) or its primary receptor tyrosine-related kinase B (TrkB) within the reward 
      pathway may modulate vulnerability to anxiety and mood disorders. The current 
      study examined the role of BDNF/TrkB signaling on biochemistry and behavior under 
      basal conditions and following exposure to a 10-day heterotypic stress paradigm 
      in male rats. Effects of intra-accumbal administration of TrkB antagonist ANA-12 
      (0.25mug/0.5mul/min) on anxiety, and expression of Trk-B, corticotropin-releasing 
      hormone (CRH), vesicular glutamate transporter 2 (vGluT2) and glucocorticoid 
      receptor (GR) within the mesolimbic pathway were determined. Notably, ANA-12 
      attenuated anxiety-like behavior in stress rats while increasing anxiety in the 
      non-stress group in the elevated plus maze (EPM). At the neurochemical level, 
      ANA-12 blocked the increased vGluT2 and CRH expressions in the hypothalamic PVN 
      and basolateral amygdala in stress rats, while it enhanced vGluT2 and CRH 
      expressions in non-stress rats. ANA-12 also showed state-dependent effects at the 
      NAc core, attenuating TrkB-ir in non-stress rats while reversing reduced 
      expression in stressed rats. At the cingulate cortex, ANA-12 normalized 
      stress-induced increase in TrkB expression. Notably, ANA-12 showed 
      region-specific effects on GR-ir at the NAc core and shell, with increased GR-ir 
      in non-stress rats, although the drug attenuated stress-induced GR-ir expression 
      only in the core portion of the NAc, while having no impact at the cingulate 
      cortex. Elevated blood CORT levels post-stress was not influenced by ANA-12 
      treatment. Together, these findings suggest that BDNF-mediated TrkB activation 
      exerts differential impact in regulating emotional response under basal and 
      stress conditions.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Azogu, Idu
AU  - Azogu I
AD  - Behavioural Neuroscience Group, School of Psychology, University of Ottawa, 136 
      Jean-Jacques Lussier, Ottawa, ON, Canada.
FAU - Plamondon, Helene
AU  - Plamondon H
AD  - Behavioural Neuroscience Group, School of Psychology, University of Ottawa, 136 
      Jean-Jacques Lussier, Ottawa, ON, Canada. Electronic address: 
      hplamond@uottawa.ca.
LA  - eng
PT  - Journal Article
DEP - 20170315
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (ANA 12 compound)
RN  - 0 (Azepines)
RN  - 0 (Benzamides)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Vesicular Glutamate Transport Protein 2)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Azepines/*pharmacology
MH  - Benzamides/*pharmacology
MH  - Corticotropin-Releasing Hormone/*metabolism
MH  - Hypothalamus/drug effects/metabolism
MH  - Limbic System/*drug effects/metabolism
MH  - Male
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/*antagonists & inhibitors
MH  - Receptors, Corticotropin-Releasing Hormone/metabolism
MH  - Receptors, Glucocorticoid/*metabolism
MH  - Signal Transduction/drug effects/physiology
MH  - Stress, Psychological/*metabolism
MH  - Vesicular Glutamate Transport Protein 2/*metabolism
OTO - NOTNLM
OT  - ANA-12
OT  - BDNF
OT  - Emotionality
OT  - HPA axis
OT  - Heterotypic stress
OT  - Nucleus accumbens
OT  - TrkB
EDAT- 2017/03/05 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/03/05 06:00
PHST- 2016/07/15 00:00 [received]
PHST- 2016/11/22 00:00 [revised]
PHST- 2017/02/22 00:00 [accepted]
PHST- 2017/03/05 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2017/03/05 06:00 [entrez]
AID - S0018-506X(16)30323-3 [pii]
AID - 10.1016/j.yhbeh.2017.02.012 [doi]
PST - ppublish
SO  - Horm Behav. 2017 Apr;90:98-112. doi: 10.1016/j.yhbeh.2017.02.012. Epub 2017 Mar 
      15.