PMID- 28257788
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20171101
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 645
DP  - 2017 Apr 3
TI  - Antidepressant-like effects of ginsenoside Rg5 in mice: Involving of hippocampus 
      BDNF signaling pathway.
PG  - 97-105
LID - S0304-3940(17)30197-0 [pii]
LID - 10.1016/j.neulet.2017.02.071 [doi]
AB  - Ginsenoside Rg5 is one of the major bioactive ingredients of Panax ginseng with 
      little toxicity and has been shown to have pharmacological effects on the central 
      nervous system. In this study, we investigated the antidepressant effects of Rg5 
      in mice models of depression. The effects of Rg5 were first assessed in the 
      forced swimming test (FST) and tail suspension test (TST), and then investigated 
      in the chronic social defeat stress (CSDS) model of depression. The changes in 
      hippocampal brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS 
      and Rg5 treatment were also examined. The tryptophan hydroxylase inhibitor and 
      tyrosine kinase B inhibitor were used to explore the antidepressant mechanisms of 
      Rg5. It was found that Rg5 exhibited antidepressant-like activities in the FST 
      and TST without affecting locomotor activity. Rg5 was also effective in the CSDS 
      model of depression, and restored the CSDS-induced decrease in hippocampal BDNF 
      signaling cascade. Moreover, the usage of the tyrosine kinase B inhibitor blocked 
      the antidepressant effects of Rg5, while the tryptophan hydroxylase inhibitor did 
      not. Collectively, ginsenoside Rg5 has antidepressant activities via the 
      activation of hippocampal BDNF system.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Xu, Dawei
AU  - Xu D
AD  - Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, 
      Nantong, 226001, People's Republic of China.
FAU - Wang, Chengniu
AU  - Wang C
AD  - Basic Medical Research Centre, Medical College, Nantong University, Nantong, 
      226001, People's Republic of China.
FAU - Zhao, Wei
AU  - Zhao W
AD  - Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, 
      Nantong, 226001, People's Republic of China.
FAU - Gao, Shengfeng
AU  - Gao S
AD  - Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, 
      Nantong, 226001, People's Republic of China.
FAU - Cui, Zhiming
AU  - Cui Z
AD  - Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, 
      Nantong, 226001, People's Republic of China. Electronic address: 
      czm_nt1y@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170301
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ginsenosides)
RN  - 0 (ginsenoside Rg5)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/drug therapy/metabolism/psychology
MH  - Dominance-Subordination
MH  - Ginsenosides/*pharmacology/therapeutic use
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Signal Transduction
MH  - Stress, Psychological/drug therapy/metabolism/psychology
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Chronic social defeat stress
OT  - Depression
OT  - Ginsenoside Rg5
EDAT- 2017/03/05 06:00
MHDA- 2017/10/11 06:00
CRDT- 2017/03/05 06:00
PHST- 2016/09/28 00:00 [received]
PHST- 2017/02/06 00:00 [revised]
PHST- 2017/02/27 00:00 [accepted]
PHST- 2017/03/05 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/03/05 06:00 [entrez]
AID - S0304-3940(17)30197-0 [pii]
AID - 10.1016/j.neulet.2017.02.071 [doi]
PST - ppublish
SO  - Neurosci Lett. 2017 Apr 3;645:97-105. doi: 10.1016/j.neulet.2017.02.071. Epub 
      2017 Mar 1.