PMID- 28257889
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20181113
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 348
DP  - 2017 Apr 21
TI  - Chronic intermittent ethanol exposure leads to alterations in brain-derived 
      neurotrophic factor within the frontal cortex and impaired behavioral flexibility 
      in both adolescent and adult rats.
PG  - 324-334
LID - S0306-4522(17)30128-8 [pii]
LID - 10.1016/j.neuroscience.2017.02.045 [doi]
AB  - Chronic intermittent exposure to ethanol (EtOH; CIE) that produces binge-like 
      levels of intoxication has been associated with age-dependent deficits in 
      cognitive functioning. Male Sprague-Dawley rats were exposed to CIE (5g/kg, 25% 
      EtOH, 13 intragastric gavages) beginning at three ages: early adolescence 
      (postnatal day [PD] 28), mid-adolescence (PD35) and adulthood (PD72). In 
      experiment 1, rats were behaviorally tested following CIE. Spatial memory was not 
      affected by CIE, but adult CIE rats were impaired at acquiring a non-spatial 
      discrimination task and subsequent reversal tasks. Rats exposed to CIE during 
      early or mid-adolescence were impaired on the first reversal, demonstrating 
      transient impairment in behavioral flexibility. Blood EtOH concentrations 
      negatively correlated with performance on reversal tasks. Experiment 2 examined 
      changes in brain-derived neurotrophic factor (BDNF) levels within the frontal 
      cortex (FC) and hippocampus (HPC) at four time points: during intoxication, 24 h 
      after the final EtOH exposure (acute abstinence), 3 weeks following abstinence 
      (recovery) and after behavioral testing. HPC BDNF levels were not affected by CIE 
      at any time point. During intoxication, BDNF was suppressed in the FC, regardless 
      of the age of exposure. However, during acute abstinence, reduced FC BDNF levels 
      persisted in early adolescent CIE rats, whereas adult CIE rats displayed an 
      increase in BDNF levels. Following recovery, neurotrophin levels in all CIE rats 
      recovered. Our results indicate that intermittent binge-like EtOH exposure leads 
      to acute disruptions in FC BDNF levels and long-lasting behavioral deficits. 
      However, the type of cognitive impairment and its duration differ depending on 
      the age of exposure.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Fernandez, Gina M
AU  - Fernandez GM
AD  - Department of Psychology, Behavioral Neuroscience Program, Binghamton University, 
      State University of New York, United States.
FAU - Lew, Brandon J
AU  - Lew BJ
AD  - Department of Psychology, Behavioral Neuroscience Program, Binghamton University, 
      State University of New York, United States.
FAU - Vedder, Lindsey C
AU  - Vedder LC
AD  - Department of Psychology, Behavioral Neuroscience Program, Binghamton University, 
      State University of New York, United States.
FAU - Savage, Lisa M
AU  - Savage LM
AD  - Department of Psychology, Behavioral Neuroscience Program, Binghamton University, 
      State University of New York, United States. Electronic address: 
      lsavage@binghamton.edu.
LA  - eng
GR  - P50 AA017823/AA/NIAAA NIH HHS/United States
GR  - R01 AA021775/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170228
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Discrimination Learning/drug effects
MH  - Ethanol/*administration & dosage
MH  - Frontal Lobe/*drug effects/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reversal Learning/drug effects
PMC - PMC5458357
MID - NIHMS862789
OTO - NOTNLM
OT  - adult
OT  - chronic intermittent ethanol exposure
OT  - discrimination learning
OT  - early adolescence
OT  - mid-adolescence
OT  - reversal learning
EDAT- 2017/03/05 06:00
MHDA- 2017/09/28 06:00
PMCR- 2018/04/21
CRDT- 2017/03/05 06:00
PHST- 2016/12/16 00:00 [received]
PHST- 2017/02/08 00:00 [revised]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/03/05 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2017/03/05 06:00 [entrez]
PHST- 2018/04/21 00:00 [pmc-release]
AID - S0306-4522(17)30128-8 [pii]
AID - 10.1016/j.neuroscience.2017.02.045 [doi]
PST - ppublish
SO  - Neuroscience. 2017 Apr 21;348:324-334. doi: 10.1016/j.neuroscience.2017.02.045. 
      Epub 2017 Feb 28.