PMID- 2825846
OWN - NLM
STAT- MEDLINE
DCOM- 19880220
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 71
IP  - 1
DP  - 1988 Jan
TI  - Establishment of a new Epstein-Barr virus-immortalized cell line from chronic 
      lymphocytic leukemia with trisomy of chromosome 12 that produces monoclonal IgM 
      against a sheep RBC antigen.
PG  - 9-12
AB  - Leukemia cells from a patient with chronic lymphocytic leukemia (CLL) were found 
      to bind sheep RBC (SRBC) through their monoclonal surface IgM. A lymphoblastoid 
      cell line was obtained by immortalization of leukemic cells with Epstein-Barr 
      virus (EBV). Cultured leukemic cells were found to have a supernumerary 
      chromosome 12, an abnormality typical of CLL of the B cell type. To our 
      knowledge, this is the first EBV-immortalized cell line from B-CLL cells of known 
      SRBC specificity and the third reported CLL cell line carrying trisomy of 
      chromosome 12.
FAU - Crescenzi, M
AU  - Crescenzi M
AD  - Department of Clinical Immunology, University of Rome, La Sapienza, Italy.
FAU - Napolitano, M
AU  - Napolitano M
FAU - Carbonari, M
AU  - Carbonari M
FAU - Antonelli, A
AU  - Antonelli A
FAU - Petrinelli, P
AU  - Petrinelli P
FAU - Gaetano, C
AU  - Gaetano C
FAU - Fiorilli, M
AU  - Fiorilli M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Neoplasm)
RN  - 0 (Antigens, Surface)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*immunology
MH  - Antibodies, Neoplasm/*immunology
MH  - Antigens, Surface/immunology
MH  - B-Lymphocytes/*immunology/ultrastructure
MH  - Cell Line
MH  - Cell Transformation, Viral
MH  - *Chromosomes, Human, Pair 12
MH  - Erythrocytes/immunology
MH  - Female
MH  - Herpesvirus 4, Human
MH  - Humans
MH  - Immunoglobulin M/*immunology
MH  - Leukemia, Lymphoid/genetics/immunology/*pathology
MH  - Middle Aged
MH  - Rosette Formation
MH  - Sheep/immunology
MH  - Trisomy
MH  - Tumor Cells, Cultured/*immunology/ultrastructure
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - S0006-4971(20)78216-9 [pii]
PST - ppublish
SO  - Blood. 1988 Jan;71(1):9-12.