PMID- 28258529
OWN - NLM
STAT- MEDLINE
DCOM- 20171027
LR  - 20181202
IS  - 1573-6776 (Electronic)
IS  - 0141-5492 (Linking)
VI  - 39
IP  - 6
DP  - 2017 Jun
TI  - Human umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease 
      through the regulation of 15-LOX-1 in macrophages.
PG  - 929-938
LID - 10.1007/s10529-017-2315-4 [doi]
AB  - OBJECTIVE: To investigate the role of human umbilical cord mesenchymal stem cells 
      (hucMSCs) in the treatment of dextran sulfate sodium (DSS)-induced inflammatory 
      bowel disease (IBD). RESULTS: ICG-hucMSCs homed to colon tissues of IBD mice 12 h 
      after injection. The injection of hucMSCs significantly relieved the IBD symptoms 
      and inflammatory cell infiltration. The expression of IL-10 gene increased while 
      those of 15-LOX-1, TNF-alpha, IL-6, IL-1beta, and IP-10 genes decreased in colon tissues 
      and spleens of hucMSCs-treated mice. The activation of STAT3 was inhibited in 
      colon tissues and spleens of IBD mice that were treated with hucMSCs. In 
      addition, the percentage of macrophages decreased in colon tissues and spleens of 
      hucMSCs-treated IBD mice. Moreover, we provided evidence that in vitro co-culture 
      with hucMSCs inhibited the expression of 15-LOX-1, IL-6 and p-STAT3 in mouse 
      enterocoelia macrophages. CONCLUSIONS: HucMSCs alleviate DSS-induced IBD through 
      the modulation of 15-LOX-1 in macrophages.
FAU - Mao, Fei
AU  - Mao F
AUID- ORCID: 0000-0001-5840-4436
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Wu, Yunbing
AU  - Wu Y
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Tang, Xudong
AU  - Tang X
AD  - Jiangsu University of Science and Technology, Zhenjiang, 212018, Jiangsu, 
      People's Republic of China.
FAU - Wang, Juanjuan
AU  - Wang J
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Pan, Zhaoji
AU  - Pan Z
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Yan, Yongmin
AU  - Yan Y
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Qian, Hui
AU  - Qian H
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China.
FAU - Xu, Wenrong
AU  - Xu W
AD  - Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, 
      School of MedicineJiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, 
      People's Republic of China. icls@ujs.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170303
PL  - Netherlands
TA  - Biotechnol Lett
JT  - Biotechnology letters
JID - 8008051
RN  - 0 (Cytokines)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, mouse)
RN  - 9042-14-2 (Dextran Sulfate)
RN  - EC 1.13.11.33 (Arachidonate 15-Lipoxygenase)
SB  - IM
MH  - Animals
MH  - Arachidonate 15-Lipoxygenase/*metabolism
MH  - Colon/metabolism
MH  - Cytokines/analysis/metabolism
MH  - Dextran Sulfate/adverse effects
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - Inflammatory Bowel Diseases/chemically induced/*surgery
MH  - Macrophages/*metabolism
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/physiology
MH  - Mice
MH  - STAT3 Transcription Factor/analysis/metabolism
MH  - Signal Transduction
MH  - Spleen/metabolism
OTO - NOTNLM
OT  - Inflammatory bowel disease
OT  - Macrophages
OT  - Mesenchymal stem cells 15-LOX-1
OT  - hucMSCs
EDAT- 2017/03/05 06:00
MHDA- 2017/10/28 06:00
CRDT- 2017/03/05 06:00
PHST- 2017/01/16 00:00 [received]
PHST- 2017/02/23 00:00 [accepted]
PHST- 2017/03/05 06:00 [pubmed]
PHST- 2017/10/28 06:00 [medline]
PHST- 2017/03/05 06:00 [entrez]
AID - 10.1007/s10529-017-2315-4 [pii]
AID - 10.1007/s10529-017-2315-4 [doi]
PST - ppublish
SO  - Biotechnol Lett. 2017 Jun;39(6):929-938. doi: 10.1007/s10529-017-2315-4. Epub 
      2017 Mar 3.