PMID- 28259063
OWN - NLM
STAT- MEDLINE
DCOM- 20171220
LR  - 20220408
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 69
DP  - 2017 Apr
TI  - To what extent does depression influence quality of life of people with 
      pharmacoresistant epilepsy in Argentina?
PG  - 133-138
LID - S1525-5050(16)30600-X [pii]
LID - 10.1016/j.yebeh.2017.01.007 [doi]
AB  - INTRODUCTION: Depression is the most frequent psychiatric co-morbidity in 
      patients with epilepsy. Lifetime prevalence of depression is reported more 
      frequently in temporal lobe epilepsy and is estimated at 35%. This co-morbidity 
      appears to be related with various mechanisms. The aim of this study was to 
      determine the quality of life (QoL) of patients with pharmacoresistant epilepsy 
      with and without co-morbid depression in an Argentinean population. METHODS: 
      Patients admitted to the video-EEG monitoring unit during the period 2010-2013 
      went through a standardized psychiatric assessment using SCID-I (Structured 
      Clinical Interview for Axis I diagnoses of DSM-IV), BDI II (Beck Depression 
      Inventory) GAF (Global assessment of functioning), and Q LES Q-SF (for quality of 
      life). Patients were divided in two groups: with and without depression 
      (according to DSM-IV). Sociodemographic data, BDI II scores, GAF, and quality of 
      life (QoL) were compared between the two groups. Comparisons were made using 
      Student's t-test and Mann-Whitney U test. Frequency distributions were compared 
      by Chi-square test. Spearman correlation coefficients were determined. RESULTS: 
      Seventy-seven patients with pharmacoresistant epilepsy were eligible for this 
      study, 41 patients were included in the group with depression (mean BDI II 
      15.93), and 36 in the group without depression (mean BDI II 3.36) (p=0.001). The 
      overall QoL was significantly lower in the group with depression compared to the 
      group without depression (p<0.01). The most affected areas were: physical health 
      (p=0.013), mood (p=0.006), course activities (referring to school as well as to 
      hobbies or classes outside of school) (p=0.003), leisure time activities 
      (p=0.011), social activities (p=0.047), general activities (p=0.042), and 
      medication (p=0.022). Severity of depression according to BDI II had a negative 
      correlation with overall QoL (r - 0.339, p<0.01). No correlations were found 
      between seizure frequency, QoL and BDI II. CONCLUSION: Patients with 
      pharmacoresistant epilepsy and co-morbid depression reported worst QoL. 
      Depression disrupts daily functioning (leisure, social functioning) and is a 
      negative influence for subjective perception of health and medication. 
      Interdisciplinary treatment should be considered 
      (neurology-psychiatry-psychotherapy).
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Scevola, Laura
AU  - Scevola L
AD  - Epilepsy Center, Ramos Mejia y El Cruce Hospital, EnyS-CONICET, Buenos Aires, 
      Argentina; Mental Health Center, Ramos Mejia Hospital, Buenos Aires, Argentina. 
      Electronic address: laurascevola@gmail.com.
FAU - Sarudiansky, Mercedes
AU  - Sarudiansky M
AD  - Epilepsy Center, Ramos Mejia y El Cruce Hospital, EnyS-CONICET, Buenos Aires, 
      Argentina.
FAU - Lanzillotti, Alejandra
AU  - Lanzillotti A
AD  - Epilepsy Center, Ramos Mejia y El Cruce Hospital, EnyS-CONICET, Buenos Aires, 
      Argentina.
FAU - Oddo, Silvia
AU  - Oddo S
AD  - Epilepsy Center, Ramos Mejia y El Cruce Hospital, EnyS-CONICET, Buenos Aires, 
      Argentina; Universidad de Buenos Aires, IBCN-CONICET, Buenos Aires, Argentina.
FAU - Kochen, Silvia
AU  - Kochen S
AD  - Epilepsy Center, Ramos Mejia y El Cruce Hospital, EnyS-CONICET, Buenos Aires, 
      Argentina; Universidad de Buenos Aires, IBCN-CONICET, Buenos Aires, Argentina.
FAU - D'Alessio, Luciana
AU  - D'Alessio L
AD  - Epilepsy Center, Ramos Mejia y El Cruce Hospital, EnyS-CONICET, Buenos Aires, 
      Argentina; Universidad de Buenos Aires, IBCN-CONICET, Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20170301
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Argentina/epidemiology
MH  - Comorbidity
MH  - Depressive Disorder/diagnosis/*epidemiology/*psychology
MH  - Drug Resistant Epilepsy/*epidemiology/*psychology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life/*psychology
MH  - Social Adjustment
MH  - Young Adult
OTO - NOTNLM
OT  - Co-morbidity
OT  - Depression
OT  - Epilepsy
OT  - Quality of life
EDAT- 2017/03/05 06:00
MHDA- 2017/12/21 06:00
CRDT- 2017/03/05 06:00
PHST- 2016/10/21 00:00 [received]
PHST- 2016/12/22 00:00 [revised]
PHST- 2017/01/07 00:00 [accepted]
PHST- 2017/03/05 06:00 [pubmed]
PHST- 2017/12/21 06:00 [medline]
PHST- 2017/03/05 06:00 [entrez]
AID - S1525-5050(16)30600-X [pii]
AID - 10.1016/j.yebeh.2017.01.007 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2017 Apr;69:133-138. doi: 10.1016/j.yebeh.2017.01.007. Epub 2017 
      Mar 1.