PMID- 2825916
OWN - NLM
STAT- MEDLINE
DCOM- 19880125
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 426
IP  - 1
DP  - 1987 Nov 17
TI  - Alpha-adrenergic mediation of the tail skin temperature response to naloxone in 
      morphine-dependent rats.
PG  - 55-61
AB  - Studies were undertaken to evaluate the role of central noradrenergic neurons in 
      the tail skin temperature (TST) surge that accompanies morphine withdrawal in the 
      rat. A 5 degrees C increase in TST and a 1-2 degrees C decrease in rectal 
      temperature (Tr) was observed following administration of a dose of naloxone HCl 
      (NAL, 1 mg/kg, s.c.) which precipitated withdrawal in morphine-dependent rats. 
      Intracerebroventricular (i.c.v.) injection of clonidine HCl, a partial alpha 
      2-adrenergic agonist did not alter TST in morphine-dependent animals. However, 
      clonidine (10 or 50 micrograms/rat, i.c.v.) given 10 min prior to the 
      administration of NAL completely blocked the TST response to the opiate 
      antagonist in the morphine-dependent animals. Although NAL and clonidine reduced 
      Tr to a similar extent in morphine-dependent rats, their effects were not 
      additive when the drugs were administered sequentially. Treatment with the 
      alpha-adrenergic antagonist phentolamine (11.9 or 60 micrograms/rat, i.c.v.) 
      failed to alter TST when administered alone, but the highest dose significantly 
      reduced the TST response to naloxone in the morphine-dependent rat. In addition, 
      phentolamine, at high doses only, moderately reduced Tr, but the alpha-adrenergic 
      antagonist failed to modify the decline in Tr associated with NAL-precipitated 
      morphine withdrawal. Collectively, these data indicate that brain noradrenergic 
      neurons play a role in the TST surge which accompanies NAL-precipitated morphine 
      withdrawal, and that the TST and Tr responses can be dissociated in the 
      morphine-dependent rat.
FAU - Katovich, M J
AU  - Katovich MJ
AD  - Department of Pharmacodynamics, College of Pharmacy, University of Florida, 
      Gainesville 32610.
FAU - Simpkins, J W
AU  - Simpkins JW
FAU - Barney, C C
AU  - Barney CC
LA  - eng
GR  - HD 18133/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 36B82AMQ7N (Naloxone)
RN  - MN3L5RMN02 (Clonidine)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Brain/*drug effects/metabolism
MH  - Clonidine/pharmacology
MH  - Female
MH  - Morphine Dependence/*metabolism
MH  - Naloxone/antagonists & inhibitors/*pharmacology
MH  - Phentolamine/pharmacology
MH  - Rats
MH  - Receptors, Adrenergic, alpha/*drug effects
MH  - Skin Temperature/drug effects
MH  - Tail/drug effects
EDAT- 1987/11/17 00:00
MHDA- 1987/11/17 00:01
CRDT- 1987/11/17 00:00
PHST- 1987/11/17 00:00 [pubmed]
PHST- 1987/11/17 00:01 [medline]
PHST- 1987/11/17 00:00 [entrez]
AID - 0006-8993(87)90424-0 [pii]
AID - 10.1016/0006-8993(87)90424-0 [doi]
PST - ppublish
SO  - Brain Res. 1987 Nov 17;426(1):55-61. doi: 10.1016/0006-8993(87)90424-0.