PMID- 28259675 OWN - NLM STAT- MEDLINE DCOM- 20180307 LR - 20180322 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 326 DP - 2017 May 30 TI - Maternal care associates with differences in morphological complexity in the medial preoptic area. PG - 22-32 LID - S0166-4328(16)31095-6 [pii] LID - 10.1016/j.bbr.2017.02.047 [doi] AB - The medial preoptic area (MPOA) is implicated in the expression of maternal behavior including the frequency of pup licking/grooming (LG) in the rat. Cyclic adenosine monophosphate (cAMP) responsive element-binding protein (CREB) is a transcription factor that regulates the expression of many genes. We found that lactating rats that are more maternal towards their pups showing increased licking/grooming (i.e. high-LG mothers) had increased levels of phosphorylated CREB (pCREB) in the MPOA following a nursing bout and they displayed a reduced population of greater dendritic complexity index (DCI) neurons compared to less maternal rats showing decreased licking/grooming (i.e. low-LG mothers). CREB overexpression in MPOA neuronal cultures associated with a decrease in dendritic complexity and an increase in the expression of Rem2 and brain-derived neurotrophic factor (BDNF), genes implicated in dendritic pruning. While there were no differences in Rem2 expression in virgin high and low-LG female rats, Rem2 was significantly increased in the MPOA of high-LG compared to low-LG lactating rats. CREB activity in the MPOA associates with maternal behavior and reduced dendritic complexity possibly by increasing Rem2 expression. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Parent, Carine AU - Parent C AD - Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada. FAU - Wen, Xianglan AU - Wen X AD - Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada. FAU - Dhir, Sabine K AU - Dhir SK AD - Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada. FAU - Ryan, Richard AU - Ryan R AD - Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada. FAU - Diorio, Josie AU - Diorio J AD - Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada. FAU - Zhang, Tie-Yuan AU - Zhang TY AD - Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, Montreal, Quebec H3A 1A1, Canada. Electronic address: tieyuan.zhang@mcgill.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170301 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.3.1.48 (CREB-Binding Protein) RN - EC 2.3.1.48 (Crebbp protein, rat) RN - EC 3.6.5.2 (Monomeric GTP-Binding Proteins) RN - EC 3.6.5.2 (Rem2 protein, rat) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - CREB-Binding Protein/*metabolism MH - Cell Culture Techniques MH - *Dendrites MH - Female MH - *Gene Expression MH - Grooming/*physiology MH - Lactation/*physiology MH - Maternal Behavior/*physiology MH - Monomeric GTP-Binding Proteins/genetics/*metabolism MH - Preoptic Area/*anatomy & histology/*metabolism MH - Rats MH - Rats, Long-Evans OTO - NOTNLM OT - BDNF OT - CREB OT - Dendritic arborization OT - Gene expression OT - Maternal behavior OT - Rem2 EDAT- 2017/03/06 06:00 MHDA- 2018/03/08 06:00 CRDT- 2017/03/06 06:00 PHST- 2016/11/18 00:00 [received] PHST- 2017/02/10 00:00 [revised] PHST- 2017/02/28 00:00 [accepted] PHST- 2017/03/06 06:00 [pubmed] PHST- 2018/03/08 06:00 [medline] PHST- 2017/03/06 06:00 [entrez] AID - S0166-4328(16)31095-6 [pii] AID - 10.1016/j.bbr.2017.02.047 [doi] PST - ppublish SO - Behav Brain Res. 2017 May 30;326:22-32. doi: 10.1016/j.bbr.2017.02.047. Epub 2017 Mar 1.