PMID- 28259985
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20181113
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 15
IP  - 4
DP  - 2017 Apr
TI  - Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review).
PG  - 1943-1951
LID - 10.3892/mmr.2017.6248 [doi]
AB  - The study of ankylosing spondylitis (AS) has made significant progress over the 
      last decade. Genome-wide association studies have identified and further 
      substantiated the role of susceptibility genes outside the major 
      histocompatibility complex locus. However, human leukocyte antigen (HLA)‑B27 has 
      been suggested to be important in the pathogenesis of AS, contributing to ~20.1% 
      of AS heritability. The current review will present the classical and 
      non‑classical forms of HLA-B27, as well as their pathogenic roles, and further 
      discuss the hypotheses regarding the potential pathogenesis of AS. In addition, 
      the association between the pathogenic role of HLA‑B27 and inflammatory indexes, 
      including the interleukin-23/‑17 axis will be investigated to provide novel 
      insights into the pathogenesis of AS. The aim of the present review is to provide 
      an update of the current research into the pathogenesis of AS, and provide a 
      comprehensive description of the pathogenic role of HLA-B27 in AS.
FAU - Chen, Bin
AU  - Chen B
AD  - Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second 
      Military Medical University, Shanghai 200433, P.R. China.
FAU - Li, Jia
AU  - Li J
AD  - Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second 
      Military Medical University, Shanghai 200433, P.R. China.
FAU - He, Chongru
AU  - He C
AD  - Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second 
      Military Medical University, Shanghai 200433, P.R. China.
FAU - Li, Dahe
AU  - Li D
AD  - Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second 
      Military Medical University, Shanghai 200433, P.R. China.
FAU - Tong, Wenwen
AU  - Tong W
AD  - Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second 
      Military Medical University, Shanghai 200433, P.R. China.
FAU - Zou, Yuming
AU  - Zou Y
AD  - Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second 
      Military Medical University, Shanghai 200433, P.R. China.
FAU - Xu, Weidong
AU  - Xu W
AD  - Department of Joint Surgery and Sports Medicine, Changhai Hospital, The Second 
      Military Medical University, Shanghai 200433, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170224
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Animals
MH  - HLA-B27 Antigen/*analysis/immunology
MH  - Humans
MH  - Protein Folding
MH  - Protein Multimerization
MH  - Proteostasis Deficiencies/immunology/pathology
MH  - Spondylitis, Ankylosing/immunology/*pathology
PMC - PMC5364987
EDAT- 2017/03/06 06:00
MHDA- 2017/05/13 06:00
PMCR- 2017/02/24
CRDT- 2017/03/06 06:00
PHST- 2015/12/11 00:00 [received]
PHST- 2016/12/21 00:00 [accepted]
PHST- 2017/03/06 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
PHST- 2017/03/06 06:00 [entrez]
PHST- 2017/02/24 00:00 [pmc-release]
AID - mmr-15-04-1943 [pii]
AID - 10.3892/mmr.2017.6248 [doi]
PST - ppublish
SO  - Mol Med Rep. 2017 Apr;15(4):1943-1951. doi: 10.3892/mmr.2017.6248. Epub 2017 Feb 
      24.