PMID- 28260301
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20221207
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 97
IP  - 8
DP  - 2017 Feb 28
TI  - [Identification of HLA class Ⅱ susceptible alleles and genotypes in latent 
      autoimmune diabetes in adults].
PG  - 581-586
LID - 10.3760/cma.j.issn.0376-2491.2017.08.005 [doi]
AB  - Objective: To identify human leukocyte antigen (HLA)-DRB1, DQA1 and DQB1 
      susceptible alleles and genotypes in latent autoimmune diabetes in adults (LADA) 
      patients of Chinese Han nationality. Methods: All subjects including 652 LADA 
      patients and 1 181 healthy controls from 1999 to 2015 in Han nationality region 
      of Hunan province were genotyped with high resolution at HLA-DRB1, DQA1 and DQB1 
      locus by PCR-sequence based typing (PCR-SBT). Frequencies of genotypes between 
      patients and controls were compared by chi square test. Results: The DQA1 
      susceptible allele was DQA1*03 (OR=1.23, P(c)=0.028); the DQB1 susceptible 
      alleles were DQB1*0201 (OR=2.24, P(c)<0.001), DQB1*0303 (OR=1.30, P(c)=0.030), 
      DQB1*0304 (OR=10.23, P(c)=0.004) and DQB1*0401(OR=1.94, P(c)<0.001); and the DRB1 
      susceptible alleles were DRB1*0301 (OR=2.10, P(c)<0.001), DRB1*0405(OR=1.89, 
      P(c)<0.001) and DRB1*0901(OR=1.36, P(c)=0.008), respectively in Chinese Han 
      nationality LADA patients. The HLA-Ⅱ susceptible genotypes were DQA1*03/05 
      (OR=1.81, P(c)=0.007), DQB1*0201/0201(OR=5.74, P(c)<0.001), DQB1*0201/0303 
      (OR=2.58, P(c)=0.010), DRB1*0301/0901(OR=3.43, P(c)=0.028) and DRB1*0901/0901 
      (OR=1.82, P(c)=0.021), respectively in LADA patients. DQB1*0201 and DRB1*0301 
      were shared susceptible alleles for Chinese Han and Caucasian LADA patients, 
      while DQA1*03, DQB1*0303, DQB1*0304, DQB1*0401, DRB1*0405 and DRB1*0901 were 
      specific susceptible alleles for Chinese Han LADA patients. Interestingly, the 
      DQB1*0303 allele was susceptible in Chinese while protective in Caucasian (OR: 
      1.30 vs 0.29). Conclusion: Susceptible alleles are DQA1*03, DQB1*0201, DQB1*0303, 
      DQB1*0304, DQB1*0401, DRB1*0301, DRB1*0405 and DRB1*0901, and susceptible 
      genotypes are DQA1*03/05, DQB1*0201/0201, DQB1*0201/0303, DRB1*0301/0901 and 
      DRB1*0901/0901 in Chinese LADA patients.
FAU - Yin, N N
AU  - Yin NN
AD  - Department of Metabolism and Endocrinology, Second Xiangya Hospital, Central 
      South University, Key Laboratory of Diabetes Immunology, Ministry of Education, 
      National Clinical Research Center for Metabolic Diseases, Changsha 410011, China.
FAU - Luo, S M
AU  - Luo SM
FAU - Lin, J
AU  - Lin J
FAU - Xie, Z G
AU  - Xie ZG
FAU - Huang, G
AU  - Huang G
FAU - Li, X
AU  - Li X
FAU - Zheng, P L
AU  - Zheng PL
FAU - Wang, J P
AU  - Wang JP
FAU - Zhou, Z G
AU  - Zhou ZG
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Asian People
MH  - Diabetes Mellitus, Type 1
MH  - *Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ beta-Chains
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - *Latent Autoimmune Diabetes in Adults
MH  - White People
OTO - NOTNLM
OT  - Alleles
OT  - Autoimmune diseases
OT  - Diabetes mellitus, type 1
OT  - Genotype
OT  - HLA
EDAT- 2017/03/06 06:00
MHDA- 2018/05/31 06:00
CRDT- 2017/03/06 06:00
PHST- 2017/03/06 06:00 [entrez]
PHST- 2017/03/06 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2017.08.005 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2017 Feb 28;97(8):581-586. doi: 
      10.3760/cma.j.issn.0376-2491.2017.08.005.