PMID- 28260421
OWN - NLM
STAT- MEDLINE
DCOM- 20180315
LR  - 20180315
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 23
IP  - 3
DP  - 2017 Mar
TI  - Successful pregnancy after natalizumab-associated progressive multifocal 
      leukoencephalopathy in a patient with multiple sclerosis.
PG  - 483-486
LID - 10.1177/1352458516678475 [doi]
AB  - We report the case of a post-progressive multifocal leukoencephalopathy (PML), 
      multiple sclerosis (MS) patient with an uncomplicated pregnancy and delivery. A 
      28-year-old woman on natalizumab (total of 49 infusions) was diagnosed with PML 
      due to typical magnetic resonance imaging (MRI) and clinical presentation. John 
      Cunningham virus (JCV) was detected in the cerebrospinal fluid (CSF) during the 
      immune reconstitution inflammatory syndrome (IRIS). Nine months after PML onset, 
      JCV negativity in the CSF was observed. MS was stabilised with dimethyl fumarate 
      (DMF), and 18 months later, a desired pregnancy was reported, resulting in the 
      birth of a healthy boy. Our report gives new hope regarding family planning for 
      post-PML patients.
FAU - Pitarokoili, Kalliopi
AU  - Pitarokoili K
AD  - Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, 
      Germany.
FAU - Hellwig, Kerstin
AU  - Hellwig K
AD  - Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, 
      Germany.
FAU - Lukas, Carsten
AU  - Lukas C
AD  - Institute of Diagnostic and Interventional Radiology, St. Josef Hospital, 
      Ruhr-University of Bochum, Bochum, Germany.
FAU - Gold, Ralf
AU  - Gold R
AD  - Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, 
      Germany.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20161112
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Natalizumab)
SB  - IM
CIN - Mult Scler. 2017 Mar;23(3):486-487. PMID: 28260414
MH  - Adult
MH  - Female
MH  - Humans
MH  - JC Virus
MH  - Leukoencephalopathy, Progressive Multifocal/*chemically induced/diagnosis
MH  - Multiple Sclerosis/complications/*drug therapy
MH  - Natalizumab/*adverse effects/therapeutic use
MH  - Pregnancy
MH  - Pregnancy Outcome
OTO - NOTNLM
OT  - Multiple sclerosis
OT  - natalizumab
EDAT- 2017/03/07 06:00
MHDA- 2018/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2017/03/07 06:00 [entrez]
PHST- 2017/03/07 06:00 [pubmed]
PHST- 2018/03/16 06:00 [medline]
AID - 10.1177/1352458516678475 [doi]
PST - ppublish
SO  - Mult Scler. 2017 Mar;23(3):483-486. doi: 10.1177/1352458516678475. Epub 2016 Nov 
      12.