PMID- 28262437
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20220318
IS  - 1873-2615 (Electronic)
IS  - 1050-1738 (Linking)
VI  - 27
IP  - 5
DP  - 2017 Jul
TI  - Myocardial fibrosis predicts ventricular tachyarrhythmias.
PG  - 363-372
LID - S1050-1738(17)30012-9 [pii]
LID - 10.1016/j.tcm.2017.01.011 [doi]
AB  - Myocardial fibrosis is a common pattern in the setting of different heart 
      diseases, and promotes ventricular tachyarrhythmias by creating a vulnerable 
      substrate for reentrant activity and by favoring the emergence of triggers. 
      Currently, late gadolinium enhancement (LGE) cardiac magnetic resonance is 
      considered the reference method for the noninvasive assessment of ventricular 
      fibrosis. Several studies and meta-analyses have shown that ventricular fibrosis 
      detected by LGE is a powerful predictor of ventricular tachyarrhythmic events in 
      ischemic, non-ischemic dilated cardiomyopathy and hypertrophic cardiomyopathy 
      patients. Both the presence and extension of ventricular fibrosis were shown to 
      correlate with the occurrence of ventricular arrhythmias and sudden cardiac 
      death, irrespective of the grade of left ventricular dysfunction. Based on these 
      results, the assessment of ventricular fibrosis has been suggested as a candidate 
      marker to improve the decision making for implantable cardioverter-defibrillator 
      therapy in patients with left ventricular dysfunction. These points will be 
      discussed in the review.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Disertori, Marcello
AU  - Disertori M
AD  - Healthcare Research and Innovation Program, PAT-FBK, Trento, Italy; Department of 
      Cardiology, Santa Chiara Hospital, Trento, Italy. Electronic address: 
      disertorim@gmail.com.
FAU - Mase, Michela
AU  - Mase M
AD  - Department of Physics, University of Trento, Povo, Trento, Italy.
FAU - Ravelli, Flavia
AU  - Ravelli F
AD  - Department of Physics, University of Trento, Povo, Trento, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170202
PL  - United States
TA  - Trends Cardiovasc Med
JT  - Trends in cardiovascular medicine
JID - 9108337
SB  - IM
CIN - Trends Cardiovasc Med. 2017 Jul;27(5):373-375. PMID: 28351697
MH  - Animals
MH  - Arrhythmias, Cardiac/diagnosis/*etiology/physiopathology/therapy
MH  - Biopsy
MH  - Cardiomyopathies/*complications/diagnostic imaging/physiopathology/*therapy
MH  - Death, Sudden, Cardiac/etiology/prevention & control
MH  - Defibrillators, Implantable
MH  - Electric Countershock/instrumentation
MH  - Electrocardiography
MH  - Fibrosis
MH  - *Heart Rate
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Treatment Outcome
MH  - *Ventricular Function
OTO - NOTNLM
OT  - Arrhythmias
OT  - Cardiomyopathy
OT  - Fibrosis
OT  - Implantable cardioverter-defibrillator
OT  - Late gadolinium enhancement
OT  - Sudden cardiac death
EDAT- 2017/03/07 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/03/07 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/01/31 00:00 [revised]
PHST- 2017/01/31 00:00 [accepted]
PHST- 2017/03/07 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/03/07 06:00 [entrez]
AID - S1050-1738(17)30012-9 [pii]
AID - 10.1016/j.tcm.2017.01.011 [doi]
PST - ppublish
SO  - Trends Cardiovasc Med. 2017 Jul;27(5):363-372. doi: 10.1016/j.tcm.2017.01.011. 
      Epub 2017 Feb 2.