PMID- 28263721
OWN - NLM
STAT- MEDLINE
DCOM- 20171128
LR  - 20171128
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 276
DP  - 2017 Oct 1
TI  - Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via 
      activation of Nrf2.
PG  - 203-209
LID - S0009-2797(17)30224-7 [pii]
LID - 10.1016/j.cbi.2017.02.020 [doi]
AB  - Methyl glyoxal (MG), a major precursor of advanced glycation end-products, has 
      been identified as significant in the progression of several diseases including 
      aging, diabetes and neurodegenerative diseases as well as causing hepatic 
      damages. 7-hydroxycoumarin (7-HC), a natural-occurring derivative of coumarin 
      from fruits and plants, has been reported to exert antioxidant and free 
      radical-scavenging properties, protecting cells from aldehydes and oxidants. In 
      this study, the ability of 7-HC to protect human HepG2 cells against MG-induced 
      toxicity and oxidative stress was investigated. Results show that 7-HC 
      pretreatment significantly attenuates MG-induced cytotoxicity, apoptotic changes 
      and ROS accumulation and that this protection is shown to be associated with the 
      induction of the nuclear factor erythroid 2-related factor 2 (NRF2) and its 
      downstream detoxifying enzymes. In response to 7-HC, NRF2 protein translocates 
      from cytosol to the nuclei. In addition, depletion of NRF2 by siRNA significantly 
      reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an 
      important role in the protective function of 7-HC. These findings highlight the 
      potential for the interventional activation of the NRF2 induction via the 
      non-toxic natural phytochemical 7-HC as a novel therapeutic approach towards the 
      detoxification of MG, with the aim of halting the progression of diseases in 
      which MG has been implicated.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Li, Dan
AU  - Li D
AD  - Collaborative Innovation Center of Yangtze River Delta Region Green 
      Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of 
      Technology, Hangzhou, 310014, China; Strathclyde Institute of Pharmacy and 
      Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 
      0RE, United Kingdom. Electronic address: lidan@zjut.edu.cn.
FAU - Wang, Na
AU  - Wang N
AD  - Collaborative Innovation Center of Yangtze River Delta Region Green 
      Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of 
      Technology, Hangzhou, 310014, China.
FAU - Zhang, Jingdong
AU  - Zhang J
AD  - Department of Medical Oncology, Cancer Hospital of China Medical University, 
      Shenyang, 110001, China.
FAU - Ma, Shuren
AU  - Ma S
AD  - Department of Endoscope, The General Hospital of Shenyang Military Region, 
      Shenyang, 110016, China.
FAU - Zhao, Zhuangzhuang
AU  - Zhao Z
AD  - Collaborative Innovation Center of Yangtze River Delta Region Green 
      Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of 
      Technology, Hangzhou, 310014, China.
FAU - Ellis, Elizabeth M
AU  - Ellis EM
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20170302
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Protective Agents)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Umbelliferones)
RN  - 60Z60NTL4G (7-hydroxycoumarin)
RN  - 722KLD7415 (Pyruvaldehyde)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspase 7)
SB  - IM
MH  - Caspase 3/metabolism
MH  - Caspase 7/metabolism
MH  - Cell Survival/drug effects
MH  - Hep G2 Cells
MH  - Humans
MH  - NF-E2-Related Factor 2/antagonists & inhibitors/genetics/*metabolism
MH  - Protective Agents/*pharmacology
MH  - Pyruvaldehyde/chemistry/*toxicity
MH  - RNA Interference
MH  - RNA, Small Interfering/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Umbelliferones/*pharmacology
OTO - NOTNLM
OT  - 7-Hydroxycoumarin
OT  - Chemoprevention
OT  - Hepatotoxicity
OT  - Methyl glyoxal
OT  - NRF2
EDAT- 2017/03/07 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/03/07 06:00
PHST- 2016/09/15 00:00 [received]
PHST- 2017/02/23 00:00 [revised]
PHST- 2017/02/27 00:00 [accepted]
PHST- 2017/03/07 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/03/07 06:00 [entrez]
AID - S0009-2797(17)30224-7 [pii]
AID - 10.1016/j.cbi.2017.02.020 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2017 Oct 1;276:203-209. doi: 10.1016/j.cbi.2017.02.020. Epub 
      2017 Mar 2.