PMID- 28264931
OWN - NLM
STAT- MEDLINE
DCOM- 20170621
LR  - 20211204
IS  - 1083-351X (Electronic)
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 292
IP  - 16
DP  - 2017 Apr 21
TI  - Key proteins and pathways that regulate lifespan.
PG  - 6452-6460
LID - 10.1074/jbc.R116.771915 [doi]
AB  - Here, we review three sets of key proteins and their corresponding downstream 
      pathways that have been linked to extending lifespan and promoting health span in 
      a wide range of organisms. In particular, we review the biology of the sirtuin 
      family of proteins, the insulin/insulin-like growth factor (IGF) signaling (IIS) 
      pathway, and the mechanistic target of rapamycin (mTOR). Using insights derived 
      from simple model organisms, mice, and humans we discuss how these proteins and 
      pathways may potentially alter the rate of aging. We further describe how 
      knowledge of these pathways may lead to the rational design of small molecules 
      that modulate aging and hence alter the propensity for a host of age-related 
      diseases.
CI  - (c) 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
FAU - Pan, Haihui
AU  - Pan H
AD  - From the Center for Molecular Medicine, NHLBI, National Institutes of Health, 
      Bethesda, Maryland 20892.
FAU - Finkel, Toren
AU  - Finkel T
AD  - From the Center for Molecular Medicine, NHLBI, National Institutes of Health, 
      Bethesda, Maryland 20892 finkelt@nih.gov.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170306
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Insulin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Caenorhabditis elegans
MH  - Caloric Restriction
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Insulin/physiology
MH  - Insulin-Like Growth Factor I/*physiology
MH  - *Longevity
MH  - Mice
MH  - Phosphorylation
MH  - Signal Transduction
MH  - Sirtuins/*physiology
MH  - TOR Serine-Threonine Kinases/*physiology
PMC - PMC5399099
OTO - NOTNLM
OT  - IGF-1
OT  - aging
OT  - insulin-like growth factor (IGF)
OT  - lifespan
OT  - mammalian target of rapamycin (mTOR)
OT  - mouse genetics
OT  - sirtuin
OT  - sirtuins
COIS- The authors declare that they have no conflicts of interest with the contents of 
      this article
EDAT- 2017/03/08 06:00
MHDA- 2017/06/22 06:00
PMCR- 2018/04/21
CRDT- 2017/03/08 06:00
PHST- 2017/03/08 06:00 [pubmed]
PHST- 2017/06/22 06:00 [medline]
PHST- 2017/03/08 06:00 [entrez]
PHST- 2018/04/21 00:00 [pmc-release]
AID - S0021-9258(20)36565-0 [pii]
AID - R116.771915 [pii]
AID - 10.1074/jbc.R116.771915 [doi]
PST - ppublish
SO  - J Biol Chem. 2017 Apr 21;292(16):6452-6460. doi: 10.1074/jbc.R116.771915. Epub 
      2017 Mar 6.