PMID- 28265256
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 8
DP  - 2017
TI  - Decreased HHV-6 IgG in Alzheimer's Disease.
PG  - 40
LID - 10.3389/fneur.2017.00040 [doi]
LID - 40
AB  - Human herpesviruses have previously been implicated in the pathogenesis of 
      Alzheimer's disease (AD) but whether they are causal, facilitating, or 
      confounding factors is yet to be established. A total of 50 AD subjects and 52 
      non-demented (ND) controls were analyzed in a multiplex assay for IgG reactivity 
      toward herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus 
      (CMV), and human herpesvirus 6 (HHV-6). The HHV-6 IgG reactivity was 
      significantly lower in AD subjects compared to ND controls, whereas there were no 
      differences in HSV, VZV, or CMV antibody levels between the groups. Analysis of 
      peripheral blood mononuclear cells with a subtype-specific HHV-6 PCR revealed no 
      signs of reactivation, as AD and ND subjects presented with comparable HHV-6 DNA 
      levels in PBMCs, and all positive samples were of subtype B. Whether HHV-6 is a 
      factor in AD remains to be elucidated in future studies.
FAU - Westman, Gabriel
AU  - Westman G
AD  - Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
FAU - Blomberg, Jonas
AU  - Blomberg J
AD  - Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
FAU - Yun, Zhibing
AU  - Yun Z
AD  - Department of Laboratory Medicine, Karolinska Institutet , Stockholm , Sweden.
FAU - Lannfelt, Lars
AU  - Lannfelt L
AD  - Department of Public Health and Caring Sciences, Uppsala University , Uppsala , 
      Sweden.
FAU - Ingelsson, Martin
AU  - Ingelsson M
AD  - Department of Public Health and Caring Sciences, Uppsala University , Uppsala , 
      Sweden.
FAU - Eriksson, Britt-Marie
AU  - Eriksson BM
AD  - Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170220
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC5316842
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - HHV-6
OT  - IgG
OT  - herpesvirus
OT  - immunoassay
OT  - multiplex
EDAT- 2017/03/08 06:00
MHDA- 2017/03/08 06:01
PMCR- 2017/02/20
CRDT- 2017/03/08 06:00
PHST- 2016/11/17 00:00 [received]
PHST- 2017/01/27 00:00 [accepted]
PHST- 2017/03/08 06:00 [entrez]
PHST- 2017/03/08 06:00 [pubmed]
PHST- 2017/03/08 06:01 [medline]
PHST- 2017/02/20 00:00 [pmc-release]
AID - 10.3389/fneur.2017.00040 [doi]
PST - epublish
SO  - Front Neurol. 2017 Feb 20;8:40. doi: 10.3389/fneur.2017.00040. eCollection 2017.