PMID- 28265344
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 8
IP  - 2
DP  - 2017 Feb 15
TI  - Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory 
      biomarkers and susceptibility to diabetic nephropathy in Asian Indians.
PG  - 66-73
LID - 10.4239/wjd.v8.i2.66 [doi]
AB  - AIM: To investigate the association of NFKB1 gene -94 ATTG insertion/deletion 
      (rs28362491) polymorphism with inflammatory markers and risk of diabetic 
      nephropathy in Asian Indians. METHODS: A total of 300 subjects were recruited 
      (100 each), normoglycemic, (NG); type 2 diabetes mellitus (T2DM) without any 
      complications (DM) and T2DM with diabetic nephropathy [DM-chronic renal disease 
      (CRD)]. Analysis was carried out by polymerase chain reaction-restriction 
      fragment length polymorphism and ELISA. Pearson's correlation, analysis of 
      variance and logistic regression were used for statistical analysis. RESULTS: The 
      allelic frequencies of -94 ATTG insertion/deletion were 0.655/0.345 (NG), 
      0.62/0.38 (DM) and 0.775/0.225 (DM-CRD). The -94 ATTG ins allele was associated 
      with significantly increased levels of urinary monocyte chemoattractant protein-1 
      (uMCP-1); uMCP-1 (P = 0.026) and plasma tumor necrosis factor-alpha (TNF-alpha); 
      TNF-alpha (P = 0.030) and almost doubled the risk of diabetic nephropathy (OR = 1.91, 
      95%CI: 1.080-3.386, P = 0.025). CONCLUSION: -94 ATTG ins/ins polymorphism might 
      be associated with increased risk of developing nephropathy in Asian Indian 
      subjects with diabetes mellitus.
FAU - Gautam, Amar
AU  - Gautam A
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
FAU - Gupta, Stuti
AU  - Gupta S
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
FAU - Mehndiratta, Mohit
AU  - Mehndiratta M
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
FAU - Sharma, Mohini
AU  - Sharma M
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
FAU - Singh, Kalpana
AU  - Singh K
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
FAU - Kalra, Om P
AU  - Kalra OP
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
FAU - Agarwal, Sunil
AU  - Agarwal S
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
FAU - Gambhir, Jasvinder K
AU  - Gambhir JK
AD  - Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University 
      College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 
      110095, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC5320420
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Inflammation
OT  - NFKB1 -94 ATTG ins/del polymorphism
OT  - Tumor necrosis factor-alpha
OT  - Urinary monocyte chemoattractant protein-1
COIS- Conflict-of-interest statement: No conflict of interest exists for this study.
EDAT- 2017/03/08 06:00
MHDA- 2017/03/08 06:01
PMCR- 2017/02/15
CRDT- 2017/03/08 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2016/12/06 00:00 [revised]
PHST- 2016/12/27 00:00 [accepted]
PHST- 2017/03/08 06:00 [entrez]
PHST- 2017/03/08 06:00 [pubmed]
PHST- 2017/03/08 06:01 [medline]
PHST- 2017/02/15 00:00 [pmc-release]
AID - 10.4239/wjd.v8.i2.66 [doi]
PST - ppublish
SO  - World J Diabetes. 2017 Feb 15;8(2):66-73. doi: 10.4239/wjd.v8.i2.66.