PMID- 28266270
OWN - NLM
STAT- MEDLINE
DCOM- 20170823
LR  - 20180605
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 24
IP  - 14
DP  - 2017
TI  - Therapeutic Strategies of Plant-derived Compounds for Diabetes Via Regulation of 
      Monocyte Chemoattractant Protein-1.
PG  - 1453-1468
LID - 10.2174/0929867324666170303162935 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC 
      chemokine family that plays a key role in the inflammatory process. It has been 
      broadly studied in the aspect of its role in obesity and diabetes related 
      diseases. MCP-1 causes the infiltration of macrophages into obese adipose tissue 
      via binding to the CCR2 receptor and is involved in the development of insulin 
      resistance. METHODS: We reviewed the available literature regarding the 
      importance of plant metabolites that regulate MCP-1 activity and are used in the 
      treatment of diabetic disorders. The characteristics of screened papers were 
      described and the important findings were included in this review. RESULTS: This 
      mini-review provides a summary of functions and therapeutic strategies of this 
      chemokine, with a special focus on plant-derived compounds that possess a 
      putative antidiabetic function via a mechanism of MCP-1 interaction. The 
      highlights of this review include the roles of MCP-1 in development of diabetes, 
      the evaluation of plant metabolites that specifically or non-specifically inhibit 
      MCP-1 overproduction, and the molecular mechanisms of this activity. Among these 
      metabolites, we particularly focused on phenolic acids and their derivatives, 
      flavonoids, stilbenes, anthocyanins, capsaicin, alkaloids, plant sterols, 
      terpenes, saponins, unsaturated fatty acids and plant-derived extracts. 
      CONCLUSION: Regarding the increasing number of diabetic patients yearly, the 
      recent progress in the putative therapies needs to be summarized. This article 
      underlines the significance and involvement of the chemokine MCP-1 in the 
      development of obesity, type 2 diabetes, and diabetic complications, with an 
      emphasis on the role of plant metabolites in the regulation of this chemokine and 
      thus the role in the prevention or therapy of diabetes. We suggest that MCP-1 
      might be a molecular marker of type 2 diabetes.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Czemplik, Magdalena
AU  - Czemplik M
AD  - Department of Physico-Chemistry of Microorganisms, Institute of Genetics and 
      Microbiology, Faculty of Biological Sciences, University of Wroclaw, Wroclaw. 
      Poland.
FAU - Kulma, Anna
AU  - Kulma A
AD  - Faculty of Biotechnology, University of Wroclaw, Wroclaw. Poland.
FAU - Wang, Yu Fu
AU  - Wang YF
AD  - Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 
      City. China.
FAU - Szopa, Jan
AU  - Szopa J
AD  - Faculty of Biotechnology, University of Wroclaw, Wroclaw. Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Alkaloids)
RN  - 0 (Anthocyanins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Flavonoids)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Sterols)
RN  - 0 (Stilbenes)
RN  - 0 (Terpenes)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Alkaloids/chemistry/isolation & purification/pharmacology
MH  - Animals
MH  - Anthocyanins/chemistry/isolation & purification/pharmacology
MH  - Capsaicin/chemistry/isolation & purification/pharmacology
MH  - Chemokine CCL2/biosynthesis/*metabolism
MH  - Diabetes Complications/*drug therapy/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Flavonoids/chemistry/isolation & purification/pharmacology
MH  - Humans
MH  - Phenols/chemistry/isolation & purification/pharmacology
MH  - Plant Extracts/*chemistry/isolation & purification/*pharmacology
MH  - Sterols/chemistry/isolation & purification/pharmacology
MH  - Stilbenes/chemistry/isolation & purification/pharmacology
MH  - Terpenes/chemistry/isolation & purification/pharmacology
OTO - NOTNLM
OT  - CCR2
OT  - Diabetes
OT  - monocyte chemoattractant protein-1 (MCP-1)
OT  - plant extracts
OT  - plant metabolites
EDAT- 2017/03/08 06:00
MHDA- 2017/08/24 06:00
CRDT- 2017/03/08 06:00
PHST- 2016/10/10 00:00 [received]
PHST- 2017/02/14 00:00 [revised]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/03/08 06:00 [pubmed]
PHST- 2017/08/24 06:00 [medline]
PHST- 2017/03/08 06:00 [entrez]
AID - CMC-EPUB-82118 [pii]
AID - 10.2174/0929867324666170303162935 [doi]
PST - ppublish
SO  - Curr Med Chem. 2017;24(14):1453-1468. doi: 10.2174/0929867324666170303162935.