PMID- 28266318 OWN - NLM STAT- MEDLINE DCOM- 20171127 LR - 20190318 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 214 DP - 2017 May TI - A randomised controlled trial of Intensive Short-Term Dynamic Psychotherapy for treatment resistant depression: the Halifax Depression Study. PG - 15-25 LID - S0165-0327(16)31572-5 [pii] LID - 10.1016/j.jad.2017.02.035 [doi] AB - BACKGROUND: While short-term psychodynamic psychotherapies have been shown effective for major depression, it is unclear if this could be a treatment of choice for depressed patients, many of whom have chronic and complex health issues, who have not sufficiently responded to treatment. METHOD: This superiority trial used a single blind randomised parallel group design to test the efficacy of time-limited Intensive Short-Term Dynamic Psychotherapy (ISTDP) for treatment resistant depression (TRD). Patients referred to secondary care community mental health teams (CMHT) who met DSM-IV criteria for major depressive episode, had received antidepressant treatment >/=6 weeks, and had Hamilton Depression Rating Scale (HAM-D) scores of >/=16 were recruited. The effects of 20 sessions of ISTDP were judged through comparison against secondary care CMHT treatment as usual (TAU). The primary outcome was HAM-D scores at 6 months. Secondary outcomes included the Patient Health Questionnaire (PHQ-9) self-report measures for depression and dichotomous measures of both remission (defined as HAM-D score