PMID- 2826715
OWN - NLM
STAT- MEDLINE
DCOM- 19880223
LR  - 20170210
IS  - 0732-183X (Print)
IS  - 0732-183X (Linking)
VI  - 6
IP  - 1
DP  - 1988 Jan
TI  - Chemotherapy-related toxicity in infants treated according to the Second National 
      Wilms' Tumor Study.
PG  - 51-5
AB  - Babies under 12 months of age have been included in the National Wilms' Tumor 
      Study (NWTS) series of clinical trials. Undue chemotherapy-related toxicity was 
      encountered early during the course of the second NWTS. The prescribed doses of 
      actinomycin D (AMD), vincristine (VCR), and Adriamycin ([ADR] doxorubicin; Adria 
      Laboratories, Columbus, OH) were therefore halved. The frequency of severe 
      hematologic toxic episodes was reduced (30 of 64 or 47% for babies receiving full 
      doses [FD], and six of 48 or 13% for those given reduced doses [RD]). Similar 
      reductions in pulmonary and hepatic effects were noted, and treatment-related 
      deaths were reduced from 6% to 0 for the FD and RD samples, respectively. These 
      frequencies among RD babies were similar to those encountered in 530 older 
      children administered FD. Reduction of dose did not compromise therapeutic 
      effectiveness.
FAU - Morgan, E
AU  - Morgan E
AD  - Children's Memorial Hospital, Chicago, IL 60614.
FAU - Baum, E
AU  - Baum E
FAU - Breslow, N
AU  - Breslow N
FAU - Takashima, J
AU  - Takashima J
FAU - D'Angio, G
AU  - D'Angio G
LA  - eng
GR  - CA-11722/CA/NCI NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of 
      Clinical Oncology
JID - 8309333
RN  - 1CC1JFE158 (Dactinomycin)
RN  - 5J49Q6B70F (Vincristine)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use
MH  - Clinical Trials as Topic
MH  - Dactinomycin/administration & dosage
MH  - Doxorubicin/administration & dosage
MH  - Hematologic Diseases/*chemically induced
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/*drug therapy
MH  - Lung Diseases/*chemically induced
MH  - Random Allocation
MH  - Vincristine/administration & dosage
MH  - Wilms Tumor/*drug therapy
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1200/JCO.1988.6.1.51 [doi]
PST - ppublish
SO  - J Clin Oncol. 1988 Jan;6(1):51-5. doi: 10.1200/JCO.1988.6.1.51.