PMID- 28267379
OWN - NLM
STAT- MEDLINE
DCOM- 20190404
LR  - 20190404
IS  - 1607-8438 (Electronic)
IS  - 0300-8207 (Linking)
VI  - 59
IP  - 1
DP  - 2018 Jan
TI  - An injectable, biodegradable calcium phosphate cement containing poly 
      lactic-co-glycolic acid as a bone substitute in ex vivo human vertebral 
      compression fracture and rabbit bone defect models.
PG  - 55-65
LID - 10.1080/03008207.2017.1301932 [doi]
AB  - Purpose/Aim of the study: To evaluate the biomechanical characteristics and 
      biocompatibility of an injectable, biodegradable calcium phosphate cement (CPC) 
      containing poly lactic-co-glycolic acid (PLGA). MATERIALS AND METHODS: A 
      vertebral compression fracture model was established using 20 human cadaveric 
      vertebrae (T11-L3) divided into CPC/PLGA composite versus PMMA groups for 
      biomechanical testing. In addition, 35 New Zealand rabbits were used to evaluate 
      biodegradability and osteoconductive properties of CPC/PLGA using a bone defect 
      model. In vitro cytotoxicity was evaluated by culturing with L929 cells. RESULTS: 
      The CPC/PLGA composite effectively restored vertebral biomechanical properties. 
      Compared with controls, the maximum load and compression strength of the CPC/PLGA 
      group were lower, and stiffness was lower after kyphoplasty (all p <.05). 
      Degradation was much slower in the control CPC compared with CPC/PLGA group. The 
      bone tissue percentage in the CPC/PLGA group (44.9 +/- 23.7%) was significantly 
      higher compared with control CPC group (25.7 +/- 10.9%) (p <.05). The viability of 
      cells cultured on CPC/PLGA was greater than 70% compared with the blanks. 
      CONCLUSIONS: Our biodegradable CPC/PLGA composite showed good biomechanical 
      properties, cytocompatibility, and osteoconductivity and may represent an ideal 
      bone substitute for future applications.
FAU - Duan, Xin
AU  - Duan X
AUID- ORCID: 0000-0002-5775-9670
AD  - a Department of Orthopedics , The First Affiliated Hospital of Sun Yat-sen 
      University , Guangzhou , China.
AD  - b Guangzhou First Municipal People's Hospital , Guangzhou , China.
FAU - Liao, Hong-Xing
AU  - Liao HX
AD  - c Division of Joint Surgery, Orthopedics Department , The Meizhou People's 
      Hospital , Meizhou , China.
FAU - Zou, Hua-Zhang
AU  - Zou HZ
AD  - d Gangwang Hospital , Guangzhou Medical College , Guangzhou , China.
FAU - Zhang, Zi-Ji
AU  - Zhang ZJ
AD  - a Department of Orthopedics , The First Affiliated Hospital of Sun Yat-sen 
      University , Guangzhou , China.
FAU - Ye, Jian-Dong
AU  - Ye JD
AD  - e Department of Materials Science and Engineering, South China University of 
      Technology , Guangzhou , China.
FAU - Liao, Wei-Ming
AU  - Liao WM
AD  - a Department of Orthopedics , The First Affiliated Hospital of Sun Yat-sen 
      University , Guangzhou , China.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - England
TA  - Connect Tissue Res
JT  - Connective tissue research
JID - 0365263
RN  - 0 (Bone Cements)
RN  - 0 (Calcium Phosphates)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - Animals
MH  - *Bone Cements/chemistry/pharmacology
MH  - *Calcium Phosphates/chemistry/pharmacology
MH  - Cell Line
MH  - Disease Models, Animal
MH  - Female
MH  - Fractures, Compression/metabolism/pathology/*therapy
MH  - Humans
MH  - Male
MH  - *Materials Testing
MH  - Mice
MH  - Middle Aged
MH  - *Polylactic Acid-Polyglycolic Acid Copolymer/chemistry/pharmacology
MH  - Rabbits
MH  - Spinal Fractures/metabolism/pathology/*therapy
OTO - NOTNLM
OT  - Biomechanics
OT  - calcium phosphate cement
OT  - cytocompatibility
OT  - degradation
OT  - experimental study
EDAT- 2017/03/08 06:00
MHDA- 2019/04/05 06:00
CRDT- 2017/03/08 06:00
PHST- 2017/03/08 06:00 [pubmed]
PHST- 2019/04/05 06:00 [medline]
PHST- 2017/03/08 06:00 [entrez]
AID - 10.1080/03008207.2017.1301932 [doi]
PST - ppublish
SO  - Connect Tissue Res. 2018 Jan;59(1):55-65. doi: 10.1080/03008207.2017.1301932. 
      Epub 2017 Apr 18.