PMID- 28267395
OWN - NLM
STAT- MEDLINE
DCOM- 20180613
LR  - 20180613
IS  - 1369-1635 (Electronic)
IS  - 0953-7104 (Linking)
VI  - 28
IP  - 8
DP  - 2017 Dec
TI  - The role of platelets in antiphospholipid syndrome.
PG  - 762-766
LID - 10.1080/09537104.2017.1280150 [doi]
AB  - Despite extensive research, the pathogenesis of antiphospholipid syndrome (APS) 
      remains obscure in many aspects. However, it is widely accepted that thrombosis 
      is the result of a hypercoagulable state caused by antibodies directed against 
      beta2-glycoprotein I (beta2-GPI), a protein whose physiological role is unknown. 
      Although underestimated, platelets may be involved in APS and its thrombotic 
      manifestations, especially arterial, in several ways. Thrombocytopenia is the 
      most relevant non-criteria manifestation of APS, possibly caused by direct 
      binding of anti-beta2-GPI antibodies or anti-beta2-GPI-beta2-GPI complexes. On the other 
      hand, platelets may have a key role in APS-related thrombosis due to the presence 
      of multiple receptors that can interact with anti-beta2-GPI antibodies (especially 
      apolipoprotein E receptor 2' (apoER2') and glycoprotein Ibalpha (GPIbalpha)) with 
      consequent release of different procoagulant mediators such as thromboxane B2, 
      platelet factor 4 (PF4), and platelet factor 4 variant (CXCL4L1). The aim of this 
      review is to put together evidence on the possible role of platelets in APS and 
      to stimulate further research on the issue.
FAU - Baroni, G
AU  - Baroni G
AD  - a Cardiology Clinic, Department of Cardiac , Thoracic, and Vascular Sciences, 
      Padua University Hospital , Padua , Italy.
FAU - Banzato, A
AU  - Banzato A
AD  - a Cardiology Clinic, Department of Cardiac , Thoracic, and Vascular Sciences, 
      Padua University Hospital , Padua , Italy.
FAU - Bison, E
AU  - Bison E
AD  - a Cardiology Clinic, Department of Cardiac , Thoracic, and Vascular Sciences, 
      Padua University Hospital , Padua , Italy.
FAU - Denas, G
AU  - Denas G
AD  - a Cardiology Clinic, Department of Cardiac , Thoracic, and Vascular Sciences, 
      Padua University Hospital , Padua , Italy.
FAU - Zoppellaro, G
AU  - Zoppellaro G
AD  - a Cardiology Clinic, Department of Cardiac , Thoracic, and Vascular Sciences, 
      Padua University Hospital , Padua , Italy.
FAU - Pengo, V
AU  - Pengo V
AD  - a Cardiology Clinic, Department of Cardiac , Thoracic, and Vascular Sciences, 
      Padua University Hospital , Padua , Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170307
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
SB  - IM
MH  - Antiphospholipid Syndrome/*blood
MH  - Blood Platelets/*metabolism
MH  - Humans
MH  - Thrombosis/*blood
OTO - NOTNLM
OT  - Antibodies
OT  - pathophysiology
OT  - phospholipids
OT  - platelets
OT  - thrombosis
EDAT- 2017/03/08 06:00
MHDA- 2018/06/14 06:00
CRDT- 2017/03/08 06:00
PHST- 2017/03/08 06:00 [pubmed]
PHST- 2018/06/14 06:00 [medline]
PHST- 2017/03/08 06:00 [entrez]
AID - 10.1080/09537104.2017.1280150 [doi]
PST - ppublish
SO  - Platelets. 2017 Dec;28(8):762-766. doi: 10.1080/09537104.2017.1280150. Epub 2017 
      Mar 7.