PMID- 28270890
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 9
IP  - 4
DP  - 2017 Apr
TI  - An Elevated HbA1c Level Is Associated With Short-Term Adverse Outcomes in 
      Patients With Gastrointestinal Cancer and Type 2 Diabetes Mellitus.
PG  - 303-309
LID - 10.14740/jocmr2607w [doi]
AB  - BACKGROUND: Although an elevated hemoglobin A1c (HbAc1) level is an independent 
      predictor of worse survival in patients with both digestive cancer and diabetes 
      mellitus, its relationship to short-term prognosis in these patients has not been 
      addressed. This study assessed this relationship in gastrointestinal cancer (GIC) 
      patients with type 2 diabetes mellitus (T2DM). METHODS: A retrospective review of 
      patients with GIC with or without T2DM from 2004 to 2014 was performed. Patients 
      with T2DM were grouped according to HbA1c level, either normal (mean < 7.0%) or 
      elevated (mean >/= 7.0%). Age- and sex-matched GIC patients without T2DM served as 
      controls. RESULTS: One hundred and eighteen patients aged 33 - 81 years with T2DM 
      met the study eligibility criteria; 51 were in the normal HbA1c group, and 67 
      were in the elevated HbA1c group. The 91 patients in the non-T2DM group were 
      randomly selected and matched to the T2DM group in terms of admittance date, age, 
      and sex. There was a trend toward a higher 180-day mortality rate in the T2DM 
      group compared with the non-T2DM group (15.3% vs. 7.7%, P = 0.095) and in the 
      elevated HbA1c group compared with the normal HbA1c group (19.4% vs. 9.8%, P = 
      0.151); however, the differences were not significant. The duration of the 
      hospital stay was longer in patients with T2DM than in those without T2DM (13.2 
      vs. 8.9 days, P < 0.05) and in patients with elevated versus normal HbA1c levels 
      (14.5 vs. 11.4 days, P < 0.05). Diabetic GIC patients with elevated HbA1c levels 
      had significantly more total postoperative complications than those with normal 
      HbA1c levels (25.4% vs. 9.8%, P < 0.05). In multivariate regression analyses, 
      short-term adverse outcomes were strongly associated with elevated HbA1c levels 
      (odds ratio (OR): 5.276; 95% confidence level (CI): 1.73 - 16.095; P < 0.05) and 
      no strict antidiabetic treatment (OR: 7.65; 95% CI: 2.49 - 23.54; P < 0.001). 
      CONCLUSION: An elevated level of HbA1c significantly correlated with and was an 
      independent predictor of short-term adverse outcomes in GIC patients with T2DM.
FAU - Huang, Yingchun
AU  - Huang Y
AD  - Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu Province, 
      China; These authors contributed equally to this work.
FAU - Zheng, Huazhen
AU  - Zheng H
AD  - Department of Clinical Laboratory, The First People's Hospital of Foshan, 
      Guangdong Province, China; These authors contributed equally to this work.
FAU - Chen, Peicong
AU  - Chen P
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China; These authors contributed equally to this work.
FAU - Yang, Jin
AU  - Yang J
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China.
FAU - Lin, Shaomin
AU  - Lin S
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China.
FAU - Liu, Tingting
AU  - Liu T
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China.
FAU - Chen, Shanwei
AU  - Chen S
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China.
FAU - Lu, Siqiang
AU  - Lu S
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China.
FAU - Chen, Junlian
AU  - Chen J
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China.
FAU - Chen, Wenpu
AU  - Chen W
AD  - First Clinical Medical College, Guangdong Medical University, Zhanjiang, 
      Guangdong Province, China; Department of Endocrinology, Affiliated Hospital of 
      Guangdong Medical University, Zhanjiang, Guangdong Province, China.
FAU - Peng, Nanhai
AU  - Peng N
AD  - Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu Province, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170221
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC5330773
OTO - NOTNLM
OT  - Gastrointestinal cancer
OT  - HbA1c
OT  - Type 2 diabetes mellitus
EDAT- 2017/03/09 06:00
MHDA- 2017/03/09 06:01
PMCR- 2017/02/21
CRDT- 2017/03/09 06:00
PHST- 2016/06/01 00:00 [accepted]
PHST- 2017/03/09 06:00 [entrez]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2017/03/09 06:01 [medline]
PHST- 2017/02/21 00:00 [pmc-release]
AID - 10.14740/jocmr2607w [doi]
PST - ppublish
SO  - J Clin Med Res. 2017 Apr;9(4):303-309. doi: 10.14740/jocmr2607w. Epub 2017 Feb 
      21.