PMID- 28271069
OWN - NLM
STAT- MEDLINE
DCOM- 20170320
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Hypofibrinolytic State in Subjects with Type 2 Diabetes Mellitus Aggravated by 
      the Metabolic Syndrome before Clinical Manifestations of Atherothrombotic 
      Disease.
PG  - 6519704
LID - 10.1155/2017/6519704 [doi]
LID - 6519704
AB  - Background. Metabolic and genetic factors induce plasminogen activator inhibitor 
      type-1 (PAI-1) overexpression; higher PAI-1 levels decrease fibrinolysis and 
      promote atherothrombosis. Aim. To assess PAI-1 antigen levels among subjects with 
      type 2 diabetes mellitus (T2DM) plus Metabolic Syndrome (MetS) before clinical 
      manifestations of atherothrombosis and the contribution of metabolic factors and 
      4G/5G polymorphism of PAI-1 gene on the variability of PAI-1. Methods. We 
      conducted an observational, cross-sectional assay in a hospital in Mexico City 
      from May 2010 to September 2011. MetS was defined by the International Diabetes 
      Federation criteria. PAI-1 levels and 4G/5G polymorphism were determined by ELISA 
      and PCR-RFLP analysis. Results. We enrolled 215 subjects with T2DM plus MetS and 
      307 controls. Subjects with T2DM plus MetS had higher PAI-1 levels than the 
      reference group (58.4 +/- 21 versus 49.9 +/- 16 ng/mL, p = 0.026). A model with 
      components of MetS explained only 12% of variability on PAI-1 levels (R(2) = 
      0.12; p = 0.001), with beta = 0.18 (p = 0.03) for hypertension, beta = -0.16 (p = 0.05) 
      for NL HDL-c, and beta = 0.15 (p = 0.05) for NL triglycerides. Conclusion. Subjects 
      with T2DM plus MetS have elevated PAI-1 levels before clinical manifestations of 
      atherothrombotic disease. Metabolic factors have a more important contribution 
      than 4G/5G polymorphism on PAI-1 plasma variability.
FAU - Aburto-Mejia, Elsa
AU  - Aburto-Mejia E
AD  - Servicio de Medicina Interna, UMAE Hospital de Especialidades, CMN Siglo XXI, 
      Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
FAU - Santiago-German, David
AU  - Santiago-German D
AD  - Servicio de Urgencias, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro", 
      Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
FAU - Martinez-Marino, Manuel
AU  - Martinez-Marino M
AD  - Servicio de Neurologia, UMAE Hospital de Especialidades, Instituto Mexicano del 
      Seguro Social, Ciudad de Mexico, Mexico.
FAU - Maria Eugenia Galvan-Plata
AU  - Maria Eugenia Galvan-Plata
AD  - Coordinacion de Investigacion en Salud, Instituto Mexicano del Seguro Social, 
      Ciudad de Mexico, Mexico.
FAU - Almeida-Gutierrez, Eduardo
AU  - Almeida-Gutierrez E
AD  - Coordinacion de Investigacion en Salud, Instituto Mexicano del Seguro Social, 
      Ciudad de Mexico, Mexico.
FAU - Lopez-Alarcon, Mardia
AU  - Lopez-Alarcon M
AUID- ORCID: 0000-0001-8017-4390
AD  - Unidad de Investigacion en Nutricion Medica, CMN Siglo XXI, Instituto Mexicano 
      del Seguro Social, Ciudad de Mexico, Mexico.
FAU - Hernandez-Juarez, Jesus
AU  - Hernandez-Juarez J
AD  - Unidad de Investigacion Medica en Trombosis, Hemostasia y Aterogenesis, H.G.R. 
      No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro", Instituto Mexicano del Seguro 
      Social, Ciudad de Mexico, Mexico.
FAU - Alvarado-Moreno, Antonio
AU  - Alvarado-Moreno A
AD  - Unidad de Investigacion Medica en Trombosis, Hemostasia y Aterogenesis, H.G.R. 
      No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro", Instituto Mexicano del Seguro 
      Social, Ciudad de Mexico, Mexico.
FAU - Leanos-Miranda, Alfredo
AU  - Leanos-Miranda A
AD  - Unidad de Investigacion Medica en Medicina Reproductiva, UMAE H.G.O. No. 4, 
      Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.
FAU - Majluf-Cruz, Abraham
AU  - Majluf-Cruz A
AUID- ORCID: 0000-0002-7697-5790
AD  - Unidad de Investigacion Medica en Trombosis, Hemostasia y Aterogenesis, H.G.R. 
      No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro", Instituto Mexicano del Seguro 
      Social, Ciudad de Mexico, Mexico.
FAU - Isordia-Salas, Irma
AU  - Isordia-Salas I
AUID- ORCID: 0000-0002-8986-2330
AD  - Unidad de Investigacion Medica en Trombosis, Hemostasia y Aterogenesis, H.G.R. 
      No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro", Instituto Mexicano del Seguro 
      Social, Ciudad de Mexico, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20170208
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Plasminogen Activator Inhibitor 1)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*blood/*complications/genetics
MH  - Female
MH  - *Fibrinolysis
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*blood/*complications/genetics
MH  - Middle Aged
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Thrombosis/*blood/*complications/genetics
PMC - PMC5320378
COIS- The authors declare that they have no competing interests.
EDAT- 2017/03/09 06:00
MHDA- 2017/03/21 06:00
PMCR- 2017/02/08
CRDT- 2017/03/09 06:00
PHST- 2016/10/13 00:00 [received]
PHST- 2016/12/13 00:00 [accepted]
PHST- 2017/03/09 06:00 [entrez]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2017/03/21 06:00 [medline]
PHST- 2017/02/08 00:00 [pmc-release]
AID - 10.1155/2017/6519704 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:6519704. doi: 10.1155/2017/6519704. Epub 2017 Feb 8.