PMID- 28271689
OWN - NLM
STAT- MEDLINE
DCOM- 20170908
LR  - 20181202
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 63
IP  - 3
DP  - 2017 Mar 1
TI  - Clinical Correlates and Reference Intervals for Cystatin C in a Han Population 
      from Southeast China.
PG  - 607-615
LID - 10.7754/Clin.Lab.2016.160807 [doi]
AB  - BACKGROUND: Cystatin C (CysC) is an endogenous filtration marker for estimation 
      of kidney function. This study aimed to define the reference interval (RI) for 
      serum CysC in a southeast Chinese adult population and to explore the variables 
      that affect serum CysC levels. METHODS: 532 reference individuals (259 male, 273 
      female, aged 18 - 79 years) were recruited from Guangzhou, China. Multiple 
      regression analysis (MRA) was used to investigate the association between serum 
      CysC levels and clinical factors including age, gender, body mass index, 
      lifestyle, and biochemistry parameters. Reference values were defined using a 
      parametric method according to Clinical and Laboratory Standards Institute 
      guideline (C28A3). RESULTS: The mean serum CysC levels were significantly lower 
      in females than in males (p < 0.001). Serum CysC levels increased with age 
      (~0.047 mg/L increase per decade). MRA demonstrated that serum CysC levels 
      correlated significantly with serum creatinine (Cr), high density lipoprotein 
      (HDL-C), alkaline phosphatase (ALP), albumin (ALB), and uric acid (UA) 
      concentrations, although their relationships were less prominent than those of 
      gender or age. The RIs for serum CysC levels were calculated at 0.73 - 1.17 mg/L 
      for subjects aged 18 - 49 years and at 0.73 - 1.49 mg/L for those aged 50 - 79 
      years. CONCLUSIONS: The RIs for serum CysC were established in a southeast 
      Chinese population. In addition to gender and age, serum Cr, HDL-C, ALP, ALB, and 
      UA also influenced serum CysC levels.
FAU - He, Min
AU  - He M
FAU - Ke, Pei-Feng
AU  - Ke PF
FAU - Chen, Wei-Ye
AU  - Chen WY
FAU - Lin, Hai-Biao
AU  - Lin HB
FAU - Wang, Yun-Xiu
AU  - Wang YX
FAU - Wan, Ze-Min
AU  - Wan ZM
FAU - Wu, Xin-Zhong
AU  - Wu XZ
FAU - Zhuang, Jun-Hua
AU  - Zhuang JH
FAU - Huang, Xian-Zhang
AU  - Huang XZ
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Biomarkers)
RN  - 0 (Cystatin C)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - China
MH  - Creatinine
MH  - Cystatin C/*analysis
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Regression Analysis
MH  - Young Adult
EDAT- 2017/03/09 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/03/09 06:00
PHST- 2017/03/09 06:00 [entrez]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2017/09/09 06:00 [medline]
AID - 10.7754/Clin.Lab.2016.160807 [doi]
PST - ppublish
SO  - Clin Lab. 2017 Mar 1;63(3):607-615. doi: 10.7754/Clin.Lab.2016.160807.