PMID- 28271947
OWN - NLM
STAT- MEDLINE
DCOM- 20230330
LR  - 20230330
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 27
IP  - 6
DP  - 2017 Nov
TI  - Health assessment questionnaire-disability index (HAQ-DI) score at the start of 
      biological disease-modifying antirheumatic drug (bDMARD) therapy is associated 
      with radiographic progression of large joint damage in patients with rheumatoid 
      arthritis.
PG  - 967-972
LID - 10.1080/14397595.2017.1294302 [doi]
AB  - OBJECTIVES: Radiographic progression of damage (RPD) to large joints in patients 
      with rheumatoid arthritis (RA) has not been fully studied. We previously 
      demonstrated that Larsen grade of the large joints was associated with RPD of 
      large joints in patients treated with biological disease-modifying anti-rheumatic 
      drugs (bDMARDs); however, no factors associated with background characteristics 
      of patients were identified. METHODS: A total of 400 large joints in the upper 
      and lower extremities, including the shoulder, elbow, knee, and ankle, of 88 
      patients with RA treated with bDMARDs for 1-3 years were investigated. 
      Radiographs of tender and/or swollen large joints were acquired at least twice 
      during the study period (mean, 16.4 months), and the RPD was evaluated. RESULTS: 
      A multivariate analysis revealed that health assessment questionnaire-disability 
      index (HAQ-DI) score at the start of bDMARD treatment was associated with RPD. 
      The cutoff value that discriminated progression from non-progression, determined 
      by a receiver operating characteristic (ROC) curve, was 1.4375 (sensitivity: 
      0.778, specificity: 0.894). CONCLUSIONS: HAQ-DI score at the start of bDMARD 
      treatment was associated with RPD to large joints during a therapeutic period of 
      1-3 years. Progressive damage is expected to increase when functional disability 
      exceeds an HAQ-DI score of 1.5.
FAU - Nakajima, Arata
AU  - Nakajima A
AD  - a Departments of Orthopaedics , Toho University Sakura Medical Center , Chiba , 
      Japan.
AD  - b Departments of Rheumatology , Toho University Sakura Medical Center , Chiba , 
      Japan.
FAU - Aoki, Yasuchika
AU  - Aoki Y
AD  - c Department of General Medical Sciences, Graduate School of Medicine , Chiba 
      University , Chiba , Japan.
AD  - d Department of Orthopaedic Surgery , Eastern Chiba Medical Center , Chiba , 
      Japan.
FAU - Terayama, Keiichiro
AU  - Terayama K
AD  - e Departments of Rehabilitation , Toho University Sakura Medical Center , Chiba , 
      Japan.
FAU - Sonobe, Masato
AU  - Sonobe M
AD  - a Departments of Orthopaedics , Toho University Sakura Medical Center , Chiba , 
      Japan.
FAU - Takahashi, Hiroshi
AU  - Takahashi H
AD  - a Departments of Orthopaedics , Toho University Sakura Medical Center , Chiba , 
      Japan.
FAU - Saito, Masahiko
AU  - Saito M
AD  - a Departments of Orthopaedics , Toho University Sakura Medical Center , Chiba , 
      Japan.
FAU - Nakagawa, Koichi
AU  - Nakagawa K
AD  - a Departments of Orthopaedics , Toho University Sakura Medical Center , Chiba , 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20170308
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Antirheumatic Agents/therapeutic use
MH  - *Arthritis, Rheumatoid/diagnostic imaging/drug therapy/pathology
MH  - Disability Evaluation
MH  - Disease Progression
MH  - Joints/diagnostic imaging/pathology
MH  - Radiography
MH  - *Severity of Illness Index
MH  - *Surveys and Questionnaires
OTO - NOTNLM
OT  - Health assessment questionnaire-disability index (HAQ-DI) score
OT  - biological disease-modifying antirheumatic drugs (bDMARDs)
OT  - large joints
OT  - radiographic progression of damage
OT  - rheumatoid arthritis
EDAT- 2017/03/09 06:00
MHDA- 2018/05/24 06:00
CRDT- 2017/03/09 06:00
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2018/05/24 06:00 [medline]
PHST- 2017/03/09 06:00 [entrez]
AID - 10.1080/14397595.2017.1294302 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2017 Nov;27(6):967-972. doi: 10.1080/14397595.2017.1294302. Epub 
      2017 Mar 8.