PMID- 28272318
OWN - NLM
STAT- MEDLINE
DCOM- 20170425
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 3
DP  - 2017 Mar 6
TI  - Epigenetic Regulation of BDNF Gene during Development and Diseases.
LID - 10.3390/ijms18030571 [doi]
LID - 571
AB  - Brain-derived neurotrophic factor (BDNF) is required for the development of the 
      nervous system, proper cognitive function and memory formation. While aberrant 
      expression of BDNF has been implicated in neurological disorders, the 
      transcriptional regulation of BDNF remains to be elucidated. In response to 
      different stimuli, BDNF expression can be initiated from different promoters. 
      Several studies have suggested that the expression of BDNF is regulated by 
      promoter methylation. An emerging theme points to the possibility that histone 
      modifications at the BDNF promoters may link to the neurological pathology. Thus, 
      understanding the epigenetic regulation at the BDNF promoters will shed light on 
      future therapies for neurological disorders. The present review summarizes the 
      current knowledge of histone modifications of the BDNF gene in neuronal diseases, 
      as well as the developmental regulation of the BDNF gene based on data from the 
      Encyclopedia of DNA Elements (ENCODE).
FAU - Chen, Kuan-Wei
AU  - Chen KW
AD  - Institute of Molecular Medicine and Department of Medical Science, National Tsing 
      Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan. 
      dreadlordpop@hotmail.com.
FAU - Chen, Linyi
AU  - Chen L
AD  - Institute of Molecular Medicine and Department of Medical Science, National Tsing 
      Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan. 
      lchen@life.nthu.edu.tw.
AD  - Department of Medical Science, National Tsing Hua University, Hsinchu 30013, 
      Taiwan. lchen@life.nthu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170306
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Histones)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Epigenesis, Genetic
MH  - *Gene Expression Regulation, Developmental
MH  - Histones/metabolism
MH  - Humans
MH  - Neurodegenerative Diseases/*genetics
MH  - Protein Processing, Post-Translational
PMC - PMC5372587
OTO - NOTNLM
OT  - BDNF
OT  - histone modification
OT  - neurodegenerative disease
OT  - neuronal development
COIS- Authors declare no conflicts of interest.
EDAT- 2017/03/09 06:00
MHDA- 2017/04/26 06:00
PMCR- 2017/03/01
CRDT- 2017/03/09 06:00
PHST- 2017/01/24 00:00 [received]
PHST- 2017/03/01 00:00 [accepted]
PHST- 2017/03/09 06:00 [entrez]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2017/04/26 06:00 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - ijms18030571 [pii]
AID - ijms-18-00571 [pii]
AID - 10.3390/ijms18030571 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Mar 6;18(3):571. doi: 10.3390/ijms18030571.