PMID- 28272702
OWN - NLM
STAT- MEDLINE
DCOM- 20170727
LR  - 20220408
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 21
IP  - 4
DP  - 2017 Feb
TI  - Clinical significance of serum MCP-1 and VE-cadherin levels in patients with 
      acute cerebral infarction.
PG  - 804-808
LID - 12245 [pii]
AB  - OBJECTIVE: Vascular injuries have been proposed to play a role in cerebral 
      infarction (CI)-induced brain damage. In this study, the expressions of monocyte 
      chemoattractant protein-1 (MCP-1) and vascular endothelial-cadherin (VE-Cadherin) 
      in patients with acute stroke was examined, and the clinical significance was 
      analyzed. PATIENTS AND METHODS: 102 patients with acute CI between February 2012 
      and 2015 were recruited in this study. Among these patients, 43 patients 
      presented with progressive cerebral infarction (PCI) while 59 patients presented 
      with non-progressive cerebral infarction (NPCI). The carotid intima-media 
      thickness (IMT) of all patients was measured by ultrasound as a marker of 
      end-organ damage. Our results showed that 26 patients had normal IMT, 19 patients 
      had a thickening carotid wall and 57 patients presented with a carotid plaque. In 
      our study, 52 healthy volunteers screened by medical checkups in our hospital 
      during the same period were taken as control group. The MCP-1 and VE-cadherin 
      expressions in each group were detected and analyzed. RESULTS: Compared to the 
      control group, the patients in the experimental group had significantly elevated 
      serum MCP-1 and VE-cadherin levels (p < 0.05). Compared to the NPCI patients, the 
      serum MCP-1 and VE-cadherin levels of the patients with PCI were significantly 
      increased, and the rate of carotid plaque was increased as well, especially in 
      the mixed echo and low echo plaques. Then compared with the patients with normal 
      IMT and thickening carotid wall, the patients with carotid plaques had notably 
      increased MCP-1 and VE-cadherin levels. CONCLUSIONS: For patients with PCI, the 
      serum MCP-1 and VE-cadherin levels were significantly increased. Moreover, serum 
      MCP-1 and VE-cadherin levels were correlated with atherosclerosis and the 
      stability of atherosclerotic plaques in patients with cerebral infarction.
FAU - He, X
AU  - He X
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, P.R. China. msrcc316@sina.com.
FAU - Li, D-R
AU  - Li DR
FAU - Cui, C
AU  - Cui C
FAU - Wen, L-J
AU  - Wen LJ
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Antigens, CD)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (cadherin 5)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD/*blood
MH  - Cadherins/*blood
MH  - Carotid Intima-Media Thickness
MH  - Case-Control Studies
MH  - Cerebral Infarction/*blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2017/03/09 06:00
MHDA- 2017/07/28 06:00
CRDT- 2017/03/09 06:00
PHST- 2017/03/09 06:00 [entrez]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2017/07/28 06:00 [medline]
AID - 12245 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2017 Feb;21(4):804-808.