PMID- 28272832
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20221207
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 40
IP  - 5
DP  - 2017 May
TI  - Left ventricular global longitudinal strain predicts mortality and heart failure 
      admissions in African American patients.
PG  - 314-321
LID - 10.1002/clc.22662 [doi]
AB  - BACKGROUND: Several studies have demonstrated the importance of left ventricular 
      (LV) global longitudinal strain (GLS) as a reliable prognostic indicator in 
      patients with heart failure (HF). These studies have included few African 
      American (AA) patients, despite the growing prevalence and severity of HF in this 
      patient population. HYPOTHESIS: LV GLS predicts long-term HF admission and 
      all-cause mortality in AA patients with chronic HF on optimal guideline-directed 
      medical therapy (GDMT). METHODS: We enrolled 207 AA adults, age 56 +/- 14.5 years, 
      with New York Heart Association (NYHA) class I through III HF on optimal GDMT 
      from the University of Illinois HF clinic between November 2001 and February 
      2014. LV GLS was assessed by velocity vector imaging using 2-, 3-, and 4-chamber 
      views. Patients were followed for HF admissions and death for 3 +/- 3.0 years. LV 
      GLS value of -7.95 was used as the optimal cutoff point that maximizes 
      sensitivity and specificity RESULTS: LV GLS < -7.95% was significantly associated 
      with higher all-cause mortality and HF admissions in Kaplan-Meier survival curves 
      (log-rank P < 0.001). After incorporation in multivariate Cox proportional hazard 
      models, GLS < -7.95% was found to be an independent predictor of all-cause 
      mortality (hazard ratio [HR] = 4.04; 95% confidence interval [CI]: 1.07-15.32; P 
      = 0.04] and HF admissions (HR = 3.86; 95% CI: 1.38-10.77; P = 0.010). 
      CONCLUSIONS: In AA patients with chronic stable HF on GDMT, more impaired LV GLS 
      (< -7.95%) is a strong and independent predictor of long-term all-cause mortality 
      and HF admissions.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Kansal, Mayank M
AU  - Kansal MM
AUID- ORCID: 0000-0003-2552-8744
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
FAU - Mansour, Ibrahim N
AU  - Mansour IN
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
FAU - Ismail, Sahar
AU  - Ismail S
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
FAU - Bress, Adam
AU  - Bress A
AD  - Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois.
FAU - Wu, Grace
AU  - Wu G
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
FAU - Mirza, Omer
AU  - Mirza O
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
FAU - Marpadga, Rahul
AU  - Marpadga R
AD  - Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois.
FAU - Gheith, Hana
AU  - Gheith H
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
FAU - Kim, Yoonsang
AU  - Kim Y
AD  - Institute for Health Research and Policy, University of Illinois at Chicago, 
      Chicago, Illinois.
FAU - Li, Yien
AU  - Li Y
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
FAU - Cavallari, Larisa
AU  - Cavallari L
AD  - Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois.
FAU - Stamos, Thomas D
AU  - Stamos TD
AD  - Department of Medicine, Division of Cardiology, University of Illinois at 
      Chicago, Chicago, Illinois.
LA  - eng
PT  - Journal Article
DEP - 20170308
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Adult
MH  - *Black or African American
MH  - Aged
MH  - Biomechanical Phenomena
MH  - Cause of Death
MH  - Chi-Square Distribution
MH  - Chicago
MH  - Comorbidity
MH  - Female
MH  - Heart Failure/diagnostic imaging/ethnology/*mortality/*physiopathology
MH  - *Hospitalization
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Myocardial Contraction
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stress, Mechanical
MH  - *Stroke Volume
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/diagnostic 
      imaging/ethnology/*mortality/*physiopathology
MH  - *Ventricular Function, Left
PMC - PMC6490368
OTO - NOTNLM
OT  - African Americans
OT  - Heart failure/cardiac transplantation/cardiomyopathy/myocarditis
OT  - Mortality
OT  - Readmission
OT  - Speckle-tracking Strain
COIS- The authors declare no potential conflict of interests.
EDAT- 2017/03/09 06:00
MHDA- 2018/03/20 06:00
PMCR- 2017/03/08
CRDT- 2017/03/09 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2016/11/22 00:00 [revised]
PHST- 2016/11/23 00:00 [accepted]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/03/09 06:00 [entrez]
PHST- 2017/03/08 00:00 [pmc-release]
AID - CLC22662 [pii]
AID - 10.1002/clc.22662 [doi]
PST - ppublish
SO  - Clin Cardiol. 2017 May;40(5):314-321. doi: 10.1002/clc.22662. Epub 2017 Mar 8.