PMID- 28273173
OWN - NLM
STAT- MEDLINE
DCOM- 20170825
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 3
DP  - 2017
TI  - Relationships between lifestyle patterns and cardio-renal-metabolic parameters in 
      patients with type 2 diabetes mellitus: A cross-sectional study.
PG  - e0173540
LID - 10.1371/journal.pone.0173540 [doi]
LID - e0173540
AB  - INTRODUCTION: While individuals tend to show accumulation of certain lifestyle 
      patterns, the effect of such patterns in real daily life on 
      cardio-renal-metabolic parameters remains largely unknown. This study aimed to 
      assess clustering of lifestyle patterns and investigate the relationships between 
      such patterns and cardio-renal-metabolic parameters. PARTICIPANTS AND METHODS: 
      The study participants were 726 Japanese type 2 diabetes mellitus (T2DM) 
      outpatients free of history of cardiovascular diseases. The relationship between 
      lifestyle patterns and cardio-renal-metabolic parameters was investigated by 
      linear and logistic regression analyses. RESULTS: Factor analysis identified 
      three lifestyle patterns. Subjects characterized by evening type, poor sleep 
      quality and depressive status (type 1 pattern) had high levels of HbA1c, alanine 
      aminotransferase and albuminuria. Subjects characterized by high consumption of 
      food, alcohol and cigarettes (type 2 pattern) had high levels of gamma-glutamyl 
      transpeptidase, triglycerides, HDL-cholesterol, blood pressure, and 
      brachial-ankle pulse wave velocity. Subjects characterized by high physical 
      activity (type 3 pattern) had low uric acid and mild elevation of alanine 
      aminotransferase and aspartate aminotransferase. In multivariate regression 
      analysis adjusted by age, gender and BMI, type 1 pattern was associated with 
      higher HbA1c levels, systolic BP and brachial-ankle pulse wave velocity. Type 2 
      pattern was associated with higher HDL-cholesterol levels, triglycerides, 
      aspartate aminotransferase, ɤ- glutamyl transpeptidase levels, and diastolic BP. 
      CONCLUSIONS: The study identified three lifestyle patterns that were associated 
      with distinct cardio-metabolic-renal parameters in T2DM patients. TRIAL 
      REGISTRATION: UMIN000010932.
FAU - Ogihara, Takeshi
AU  - Ogihara T
AD  - Department of Metabolism & Endocrinology, Tokyo, Japan.
FAU - Mita, Tomoya
AU  - Mita T
AUID- ORCID: 0000-0002-4401-2965
AD  - Department of Metabolism & Endocrinology, Tokyo, Japan.
AD  - Center for Therapeutic Innovations in Diabetes, Tokyo, Japan.
FAU - Osonoi, Yusuke
AU  - Osonoi Y
AD  - Department of Metabolism & Endocrinology, Tokyo, Japan.
FAU - Osonoi, Takeshi
AU  - Osonoi T
AD  - Naka Memorial Clinic, Naka City, Ibaraki, Japan.
FAU - Saito, Miyoko
AU  - Saito M
AD  - Naka Memorial Clinic, Naka City, Ibaraki, Japan.
FAU - Tamasawa, Atsuko
AU  - Tamasawa A
AD  - Naka Memorial Clinic, Naka City, Ibaraki, Japan.
FAU - Nakayama, Shiho
AU  - Nakayama S
AD  - Department of Metabolism & Endocrinology, Tokyo, Japan.
FAU - Someya, Yuki
AU  - Someya Y
AD  - Department of Metabolism & Endocrinology, Tokyo, Japan.
FAU - Ishida, Hidenori
AU  - Ishida H
AD  - Naka Memorial Clinic, Naka City, Ibaraki, Japan.
FAU - Gosho, Masahiko
AU  - Gosho M
AD  - Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, 
      University of Tsukuba, Tsukuba, Ibaraki, Japan.
FAU - Kanazawa, Akio
AU  - Kanazawa A
AD  - Department of Metabolism & Endocrinology, Tokyo, Japan.
AD  - Center for Therapeutic Innovations in Diabetes, Tokyo, Japan.
FAU - Watada, Hirotaka
AU  - Watada H
AD  - Department of Metabolism & Endocrinology, Tokyo, Japan.
AD  - Center for Therapeutic Innovations in Diabetes, Tokyo, Japan.
AD  - Center for Molecular Diabetology, Tokyo, Japan.
AD  - Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170308
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Cardiovascular Diseases/*complications/*metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Kidney Diseases/*complications/*metabolism
MH  - *Life Style
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Surveys and Questionnaires
PMC - PMC5342268
COIS- Competing Interests: H.W. has received lecture fees from Boehringer Ingelheim, 
      Sanofi-Aventis, Ono Pharmaceutical Co., Novo Nordisk Pharma, Novartis 
      Pharmaceuticals, Eli Lilly, Sanwakagaku Kenkyusho, Daiichi Sankyo Inc., Takeda 
      Pharmaceutical Co., MSD, Dainippon Sumitomo Pharm., Kowa Co. and research funds 
      from Boehringer Ingelheim, Pfizer, Mochida Pharmaceutical Co., Sanofi-Aventis, 
      Novo Nordisk Pharma, Novartis Pharmaceuticals, Sanwakagaku Kenkyusho, Terumo 
      Corp. Eli Lilly, Mitsubishi Tanabe Pharma, Daiichi Sankyo Inc., Takeda 
      Pharmaceutical Co., MSD, Shionogi, Pharma, Dainippon Sumitomo Pharma, Kissei 
      Pharma, and Astrazeneca. Other authors have no conflicting interests. This does 
      not alter our adherence to PLOS ONE policies on sharing data and materials.
EDAT- 2017/03/09 06:00
MHDA- 2017/08/26 06:00
PMCR- 2017/03/08
CRDT- 2017/03/09 06:00
PHST- 2016/12/24 00:00 [received]
PHST- 2017/02/22 00:00 [accepted]
PHST- 2017/03/09 06:00 [entrez]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2017/08/26 06:00 [medline]
PHST- 2017/03/08 00:00 [pmc-release]
AID - PONE-D-16-50889 [pii]
AID - 10.1371/journal.pone.0173540 [doi]
PST - epublish
SO  - PLoS One. 2017 Mar 8;12(3):e0173540. doi: 10.1371/journal.pone.0173540. 
      eCollection 2017.