PMID- 28273631
OWN - NLM
STAT- MEDLINE
DCOM- 20180214
LR  - 20181202
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 89
DP  - 2017 May
TI  - Protective effects of N-acetylcystein and atorvastatin against renal and hepatic 
      injury in a rat model of intestinal ischemia-reperfusion.
PG  - 673-680
LID - S0753-3322(17)30622-4 [pii]
LID - 10.1016/j.biopha.2017.02.086 [doi]
AB  - AIM OF THE STUDY: We sought to examine whether the separate and combined effect 
      of N-acetylcystein (NAC) and atorvastatin prevented hepatic and renal tissue 
      injury induced by intestinal ischemia-reperfusion (I/R). MATERIAL AND METHODS: 40 
      male Wistar rats were allocated into 5 experimental groups; Control (n=8): sham, 
      I/R (n=8): rats underwent occlusion of superior mesenteric artery for 45min, 
      Atorvastatin (n=8): rats received 10mg/kg atorvastatin, NAC (n=8): rats received 
      160mg/kg NAC, NAC&Atorvastatin (n=8): rats received both aforementioned agents. 
      Administration of the agents was facilitated by oral gavage 24h before I/R. Serum 
      levels of urea, creatinine, transaminases, IL-1beta, IL-6, TNF-alpha, ICAM-1, as well as 
      liver and kidney histopathological examination were evaluated. RESULTS: 
      Pretreatment with either NAC or Atorvastatin or their combination led to lower 
      levels of transaminases and ICAM-1 (2.75+/-0.46, 2.88+/-0.84 and 1.5+/-0.76 
      respectively for NAC, Atorvastatin and I/R groups), while only their combination 
      led to lower ratios of IL-1, IL-6 and TNF-alpha than I/R group (1.3+/-0.12 vs 
      1.94+/-0.54, 1.21+/-0.11 vs 2.12+/-0.96 and 1.33+/-0.11 vs 2.14+/-0.77, respectively). NAC 
      was associated with enhanced renal tissue histology, while atorvastatin was found 
      superior in protecting hepatic tissue degenaration. CONCLUSIONS: Both agents, 
      seperately and combined, seem to exhibited tissue-specific protective activity 
      against intestinal I/R induced injury.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Alexandropoulos, Dimitrios
AU  - Alexandropoulos D
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Bazigos, Gerasimos V
AU  - Bazigos GV
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Doulamis, Ilias P
AU  - Doulamis IP
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece. 
      Electronic address: doulamis.i@gmail.com.
FAU - Tzani, Aspasia
AU  - Tzani A
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Konstantopoulos, Panagiotis
AU  - Konstantopoulos P
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Tragotsalou, Nikolitsa
AU  - Tragotsalou N
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Kondi-Pafiti, Agathi
AU  - Kondi-Pafiti A
AD  - Department of Pathology, Aretaieion Hospital, Medical School, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Kotsis, Thomas
AU  - Kotsis T
AD  - Vascular Unit, 2nd Clinic of Surgery, Aretaieion Hospital, Medical School, 
      National and Kapodistrian University of Athens, Athens, Greece, Greece.
FAU - Arkadopoulos, Nikolaos
AU  - Arkadopoulos N
AD  - 4th Department of Surgery, ATTIKON University Hospital, Medical School, National 
      and Kapodistrian University of Athens, Athens, Greece.
FAU - Smyrniotis, Vasileios
AU  - Smyrniotis V
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Perrea, Despina N
AU  - Perrea DN
AD  - Laboratory for Experimental Surgery and Surgical Research "N.S Christeas", 
      Medical School, National and Kapodistrian University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antioxidants)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Protective Agents)
RN  - A0JWA85V8F (Atorvastatin)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - Acute Kidney Injury/pathology/*prevention & control
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Atorvastatin/*pharmacology
MH  - Drug Therapy, Combination
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
MH  - Intestines/*blood supply
MH  - Kidney Function Tests
MH  - Liver Diseases/pathology/*prevention & control
MH  - Liver Function Tests
MH  - Male
MH  - Protective Agents/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/pathology/*prevention & control
OTO - NOTNLM
OT  - Atrorvastatin
OT  - Intestinal
OT  - Ischemia-reperfusion
OT  - N-Acetylcystein
OT  - Rats
EDAT- 2017/03/09 06:00
MHDA- 2018/02/15 06:00
CRDT- 2017/03/09 06:00
PHST- 2017/02/09 00:00 [received]
PHST- 2017/02/22 00:00 [revised]
PHST- 2017/02/22 00:00 [accepted]
PHST- 2017/03/09 06:00 [pubmed]
PHST- 2018/02/15 06:00 [medline]
PHST- 2017/03/09 06:00 [entrez]
AID - S0753-3322(17)30622-4 [pii]
AID - 10.1016/j.biopha.2017.02.086 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 May;89:673-680. doi: 10.1016/j.biopha.2017.02.086. Epub 
      2017 Mar 6.