PMID- 28273811
OWN - NLM
STAT- MEDLINE
DCOM- 20170420
LR  - 20220321
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 3
DP  - 2017 Mar 3
TI  - Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 
      and Their Relevance for Treatment of Spinal Cord Injury.
LID - 10.3390/ijms18030548 [doi]
LID - 548
AB  - Neurotrophins are a family of proteins that regulate neuronal survival, synaptic 
      function, and neurotransmitter release, and elicit the plasticity and growth of 
      axons within the adult central and peripheral nervous system. Since the 1950s, 
      these factors have been extensively studied in traumatic injury models. Here we 
      review several members of the classical family of neurotrophins, the receptors 
      they bind to, and their contribution to axonal regeneration and sprouting of 
      sensory and motor pathways after spinal cord injury (SCI). We focus on nerve 
      growth factor (NGF), brain derived neurotrophic factor (BDNF), and neurotrophin-3 
      (NT-3), and their effects on populations of neurons within diverse spinal tracts. 
      Understanding the cellular targets of neurotrophins and the responsiveness of 
      specific neuronal populations will allow for the most efficient treatment 
      strategies in the injured spinal cord.
FAU - Keefe, Kathleen M
AU  - Keefe KM
AD  - Shriners Hospital's Pediatric Research Center (Center for Neural Repair and 
      Rehabilitation), Lewis Katz School of Medicine at Temple University, 6th Floor 
      Medical Education & Research Building, 3500 N. Broad Street, Philadelphia, PA 
      19140-4106, USA. kathymkeefe@temple.edu.
FAU - Sheikh, Imran S
AU  - Sheikh IS
AD  - Shriners Hospital's Pediatric Research Center (Center for Neural Repair and 
      Rehabilitation), Lewis Katz School of Medicine at Temple University, 6th Floor 
      Medical Education & Research Building, 3500 N. Broad Street, Philadelphia, PA 
      19140-4106, USA. sheikh@temple.edu.
FAU - Smith, George M
AU  - Smith GM
AD  - Shriners Hospital's Pediatric Research Center (Center for Neural Repair and 
      Rehabilitation), Lewis Katz School of Medicine at Temple University, 6th Floor 
      Medical Education & Research Building, 3500 N. Broad Street, Philadelphia, PA 
      19140-4106, USA. tue44530@temple.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170303
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Humans
MH  - Molecular Targeted Therapy
MH  - Nerve Growth Factor/metabolism
MH  - Nerve Growth Factors/*metabolism/pharmacology/therapeutic use
MH  - Nerve Regeneration/drug effects
MH  - Neural Pathways/drug effects
MH  - Neurons/drug effects/*metabolism
MH  - Neurotrophin 3/metabolism
MH  - Protein Binding
MH  - Signal Transduction/drug effects
MH  - Spinal Cord Injuries/drug therapy/etiology/*metabolism
PMC - PMC5372564
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - nerve growth factor
OT  - neuroprotection
OT  - neurotrophic factors
OT  - neurotrophin-3
OT  - plasticity
OT  - regeneration
OT  - spinal cord injury
COIS- The authors declare no conflict of interest.
EDAT- 2017/03/10 06:00
MHDA- 2017/04/21 06:00
PMCR- 2017/03/01
CRDT- 2017/03/10 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/02/23 00:00 [revised]
PHST- 2017/02/24 00:00 [accepted]
PHST- 2017/03/10 06:00 [entrez]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/04/21 06:00 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - ijms18030548 [pii]
AID - ijms-18-00548 [pii]
AID - 10.3390/ijms18030548 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Mar 3;18(3):548. doi: 10.3390/ijms18030548.