PMID- 28274306
OWN - NLM
STAT- MEDLINE
DCOM- 20170914
LR  - 20170914
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 33
IP  - 3
DP  - 2017 Mar
TI  - [Glycyrrhizinic acid modulates the immunity of MRL/lpr mice and related 
      mechanism].
PG  - 305-309
AB  - Objective To investigate the immunological effect of glycyrrhizic acid (GA) on 
      MRL/lpr mice and its underlying mechanism. Methods The research included 10 wild 
      type C57BL/6 mice and 40 MRL/lpr mice. MRL/lpr mice were randomly assigned to 
      four groups: MRL/lpr control, MRL/lpr treated with dexamethasone (1.5 mg/kg), 
      MRL/lpr treated with GA (20 mg/kg) and GA (40 mg/kg), 10 mice in each group. The 
      serum levels of interleukin 4 (IL-4) and interferon-gamma (IFN-gamma) were tested by 
      ELISA. The ratio of Th1/Th2 cell subsets in spleen was analyzed by flow 
      cytometry. The protein levels of GATA-binding protein 3 (GATA3), T-bet, p-JAK3, 
      JAK3, phosphorylated signal transducer and activator of transcription 3 
      (p-STAT3), STAT3, p-NF-kappaBp65, NF-kappaBp65, p-IkappaBalpha, IkappaBalpha in spleen were detected by 
      Western blot analysis. Results GA decreased serum levels of IL-4 and increased 
      IFN-gamma, modulated the balance of Th1/Th2 cell subsets in spleen markedly. GA 
      inhibited the protein levels of GATA3, p-JAK3, p-STAT3, p-NF-kappaB, p-IkappaBalpha and 
      increased T-bet protein in MRL/lpr mice. Conclusion Administration of GA can 
      ameliorate the immune function in MRL/lpr mice.
FAU - Wang, Yuanyuan
AU  - Wang Y
AD  - Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, 
      China.
FAU - Chai, Jixia
AU  - Chai J
AD  - Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, 
      China.
FAU - Sun, Meiqun
AU  - Sun M
AD  - Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, 
      China.
FAU - He, Wenxin
AU  - He W
AD  - Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, 
      China.
FAU - Hu, Xiaodong
AU  - Hu X
AD  - Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, 
      China.
FAU - Zou, Weiyan
AU  - Zou W
AD  - Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, 
      China.
FAU - Li, Huihui
AU  - Li H
AD  - Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, 
      China.
FAU - Lu, Yang
AU  - Lu Y
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital, Bengbu 
      Medical College, Bengbu 233004, China.
FAU - Xie, Changhao
AU  - Xie C
AD  - Department of Rheumatology and Immunology, First Affiliated Hospital, Bengbu 
      Medical College, Bengbu 233004, China. *Corresponding author, E-mail: 
      uglboy2002@126.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (NF-kappa B)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - GATA3 Transcription Factor/genetics/immunology
MH  - Glycyrrhizic Acid/*administration & dosage
MH  - Humans
MH  - Immunity/*drug effects
MH  - Interferon-gamma/genetics/immunology
MH  - Lupus Erythematosus, Systemic/*drug therapy/genetics/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred MRL lpr
MH  - NF-kappa B/genetics/immunology
MH  - Th1 Cells/drug effects/immunology
MH  - Th2 Cells/drug effects/immunology
EDAT- 2017/03/10 06:00
MHDA- 2017/09/15 06:00
CRDT- 2017/03/10 06:00
PHST- 2017/03/10 06:00 [entrez]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/09/15 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Mar;33(3):305-309.