PMID- 28274716
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20171209
IS  - 1090-2422 (Electronic)
IS  - 0014-4827 (Linking)
VI  - 353
IP  - 1
DP  - 2017 Apr 1
TI  - Atractylenolide I restores HO-1 expression and inhibits Ox-LDL-induced VSMCs 
      proliferation, migration and inflammatory responses in vitro.
PG  - 26-34
LID - S0014-4827(17)30094-0 [pii]
LID - 10.1016/j.yexcr.2017.02.040 [doi]
AB  - Pathogenesis of atherosclerosis is characterized by the proliferation and 
      migration of vascular smooth muscle cells (VSMCs) and inflammatory lesions. The 
      aim of this study is to elucidate the effect of atractylenolide I (AO-I) on 
      smooth muscle cell inflammation, proliferation and migration induced by oxidized 
      modified low density lipoprotein (Ox-LDL). Here, We found that atractylenolide I 
      inhibited Ox-LDL-induced VSMCs proliferation and migration in a dose-dependent 
      manner, and decreased the production of inflammatory cytokines and the expression 
      of monocyte chemoattractant protein-1 (MCP-1) in VSMCs. The study also identified 
      that AO-I prominently inhibited p38-MAPK and NF-kappaB activation. More importantly, 
      the specific heme oxygenase-1 (HO-1) inhibitor zinc protoporphyrin (ZnPP) IX 
      partially abolished the beneficial effects of atractylenolide I on Ox-LDL-induced 
      VSMCs. Furthermore, atractylenolide I blocked the foam cell formation in 
      macrophages induced by Ox-LDL. In summary, inhibitory roles of AO-I in VSMCs 
      proliferation and migration, lipid peroxidation and subsequent inflammatory 
      responses might contribute to the anti-atherosclerotic property of AO-I.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Li, Weifeng
AU  - Li W
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic 
      address: liwf@mail.xjtu.edu.cn.
FAU - Zhi, Wenbing
AU  - Zhi W
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China.
FAU - Liu, Fang
AU  - Liu F
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China.
FAU - He, Zehong
AU  - He Z
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China.
FAU - Wang, Xiuei
AU  - Wang X
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China.
FAU - Niu, Xiaofeng
AU  - Niu X
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic 
      address: niuxf@mail.xjtu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170306
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Lactones)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Sesquiterpenes)
RN  - 0 (atractylenolide I)
RN  - 0 (oxidized low density lipoprotein)
RN  - EC 1.14.14.18 (HMOX1 protein, human)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/drug therapy/immunology/pathology
MH  - Cell Movement/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Drug Evaluation, Preclinical
MH  - Female
MH  - Foam Cells/drug effects/physiology
MH  - Heme Oxygenase-1/*genetics/metabolism
MH  - Lactones/*pharmacology
MH  - Lipoproteins, LDL/*physiology
MH  - Male
MH  - Mice
MH  - Muscle, Smooth, Vascular/cytology
MH  - Myocytes, Smooth Muscle/drug effects/*physiology
MH  - Rats, Sprague-Dawley
MH  - Sesquiterpenes/*pharmacology
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Atractylenolide I
OT  - Inflammation
OT  - Migration
OT  - Proliferation
OT  - Vascular smooth muscle cells
EDAT- 2017/03/10 06:00
MHDA- 2017/05/16 06:00
CRDT- 2017/03/10 06:00
PHST- 2016/11/02 00:00 [received]
PHST- 2017/02/21 00:00 [revised]
PHST- 2017/02/27 00:00 [accepted]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2017/03/10 06:00 [entrez]
AID - S0014-4827(17)30094-0 [pii]
AID - 10.1016/j.yexcr.2017.02.040 [doi]
PST - ppublish
SO  - Exp Cell Res. 2017 Apr 1;353(1):26-34. doi: 10.1016/j.yexcr.2017.02.040. Epub 
      2017 Mar 6.