PMID- 28274943
OWN - NLM
STAT- MEDLINE
DCOM- 20171004
LR  - 20180203
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 101
IP  - 10
DP  - 2017 Oct
TI  - Functional analysis and associated factors of the peripapillary retinal nerve 
      fibre layer in former preterm and full-term infants.
PG  - 1405-1411
LID - 10.1136/bjophthalmol-2016-309622 [doi]
AB  - PURPOSE: The aim of the study was to investigate peripapillary retinal nerve 
      fibre layer thickness (RNFLT) in former preterm infants and full-term neonates 
      using spectral-domain optical coherence tomography (SD-OCT). METHODS: The 
      prospective, controlled, cross-sectional, hospital-based study in a tertiary 
      centre with maximum care examined 503 infants with a former gestational age (GA) 
      of >/=37 and </=32 weeks now aged between 4 and 10 years. In total, we analysed 432 
      participants with successful circular peripapillary RNFLT OCT measurements. Main 
      outcome measures were RNFLT correlations to GA, birth weight, occurrence of 
      retinopathy of prematurity (ROP), perinatal adverse events as well as functional 
      correlation. RESULTS: Global RNFLT was thinner in infants with GA </=28 weeks 
      compared with infants with GA between 29 and 32 weeks (p=0.024), and to full-term 
      neonates (p=0.007) independent of the occurrence of ROP. Multivariable analysis 
      revealed that RNFLT was positively associated with higher birth weight and GA. 
      Furthermore, a decrease of RNFLT was related to reduced visual function in all 
      peripapillary sectors. CONCLUSIONS: The main factors for retinal nerve fibre 
      layer thinning are low birth weight and low GA. In addition, decreased RNFLT was 
      associated with reduced visual function. This demonstrates that preterm infants 
      are at high risk for peripapillary RNFL damage associated with reduced visual 
      function.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Fiess, Achim
AU  - Fiess A
AD  - Department of Ophthalmology, Helios Dr Horst Schmidt Klinik, Wiesbaden, Germany.
FAU - Christian, Luka
AU  - Christian L
AD  - Department of Paediatrics, Helios Dr Horst Schmidt Klinik, Wiesbaden, Germany.
FAU - Janz, Johannes
AU  - Janz J
AD  - Department of Paediatrics, Helios Dr Horst Schmidt Klinik, Wiesbaden, Germany.
FAU - Kolb-Keerl, Ruth
AU  - Kolb-Keerl R
AD  - Department of Ophthalmology, Helios Dr Horst Schmidt Klinik, Wiesbaden, Germany.
FAU - Knuf, Markus
AU  - Knuf M
AD  - Department of Paediatrics, Helios Dr Horst Schmidt Klinik, Wiesbaden, Germany.
FAU - Kirchhof, Bernd
AU  - Kirchhof B
AD  - Department of Ophthalmology, University of Cologne, Cologne, Germany.
FAU - Muether, Philipp S
AU  - Muether PS
AD  - Department of Ophthalmology, University of Cologne, Cologne, Germany.
FAU - Bauer, Jacqueline
AU  - Bauer J
AD  - Department of Paediatrics, Helios Dr Horst Schmidt Klinik, Wiesbaden, Germany.
CN  - Prematurity Eye Study Group
LA  - eng
PT  - Journal Article
DEP - 20170308
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Premature
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Organ Size
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Retinopathy of Prematurity/epidemiology/pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
OTO - NOTNLM
OT  - Child health (paediatrics)
OT  - Imaging
OT  - Optic Nerve
OT  - Retina
OT  - Visual perception
COIS- Competing interests: None declared.
FIR - Demirbas, Serife
IR  - Demirbas S
FIR - Di Oliveira, Paula Divis
IR  - Di Oliveira PD
FIR - Ernst, Lisa
IR  - Ernst L
FIR - Ghafoori, Shirin
IR  - Ghafoori S
FIR - Jordan, Saskia
IR  - Jordan S
FIR - Nikolic, Petra
IR  - Nikolic P
FIR - Scheele, David
IR  - Scheele D
FIR - Tlucynski, Florian
IR  - Tlucynski F
FIR - Zeymer, Christine
IR  - Zeymer C
EDAT- 2017/03/10 06:00
MHDA- 2017/10/05 06:00
CRDT- 2017/03/10 06:00
PHST- 2016/09/05 00:00 [received]
PHST- 2017/01/19 00:00 [revised]
PHST- 2017/02/10 00:00 [accepted]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/10/05 06:00 [medline]
PHST- 2017/03/10 06:00 [entrez]
AID - bjophthalmol-2016-309622 [pii]
AID - 10.1136/bjophthalmol-2016-309622 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2017 Oct;101(10):1405-1411. doi: 
      10.1136/bjophthalmol-2016-309622. Epub 2017 Mar 8.