PMID- 28275510
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2090-1232 (Print)
IS  - 2090-1224 (Electronic)
IS  - 2090-1224 (Linking)
VI  - 7
IP  - 5
DP  - 2016 Sep
TI  - Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: 
      A review.
PG  - 719-726
LID - 10.1016/j.jare.2016.04.001 [doi]
AB  - Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular 
      cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed 
      parts of the body along with specific serum autoantibodies (i.e. antinuclear 
      antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug 
      induced. The role of chemotherapeutic agents in causing SCLE has been 
      investigated with the taxanes being the most common anticancer agents. However, 
      recent data emerging point toward antiestrogen therapies as a causative factor 
      not only for SCLE but also for a variety of autoimmune disorders. This is a 
      report of a case of a 42 year old woman who developed clinical manifestations of 
      SCLE after letrozole treatment in whom remission of the cutaneous manifestations 
      was noticed upon discontinuation of the drug. In addition, an extensive review of 
      the English literature has been performed regarding the association of 
      antiestrogen therapy with autoimmune disorders. In conclusion, Oncologists should 
      be aware of the potential development of autoimmune reactions in breast cancer 
      patients treated with aromatase inhibitors.
FAU - Zarkavelis, George
AU  - Zarkavelis G
AD  - Department of Medical Oncology, Ioannina University Hospital, S. Niarchos Avenue, 
      45500 Ioannina, Greece.
FAU - Kollas, Aristomenes
AU  - Kollas A
AD  - Department of Medical Oncology, Ioannina University Hospital, S. Niarchos Avenue, 
      45500 Ioannina, Greece.
FAU - Kampletsas, Eleftherios
AU  - Kampletsas E
AD  - Department of Medical Oncology, Ioannina University Hospital, S. Niarchos Avenue, 
      45500 Ioannina, Greece.
FAU - Vasiliou, Vasilis
AU  - Vasiliou V
AD  - Department of Dermatology, Ioannina University Hospital, S. Niarchos Avenue, 
      45500 Ioannina, Greece.
FAU - Kaltsonoudis, Evripides
AU  - Kaltsonoudis E
AD  - Rheumatology Clinic, Department of Internal Medicine, Ioannina University 
      Hospital, S. Niarchos Avenue, 45500 Ioannina, Greece.
FAU - Drosos, Alexandros
AU  - Drosos A
AD  - Rheumatology Clinic, Department of Internal Medicine, Ioannina University 
      Hospital, S. Niarchos Avenue, 45500 Ioannina, Greece.
FAU - Khaled, Hussein
AU  - Khaled H
AD  - Medical Oncology, National Cancer Institute, Cairo University, Cairo 11796, 
      Egypt.
FAU - Pavlidis, Nicholas
AU  - Pavlidis N
AD  - Department of Medical Oncology, Ioannina University Hospital, S. Niarchos Avenue, 
      45500 Ioannina, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160423
PL  - Egypt
TA  - J Adv Res
JT  - Journal of advanced research
JID - 101546952
PMC - PMC5328027
OTO - NOTNLM
OT  - Aromatase inhibitors
OT  - Arthralgias
OT  - Breast cancer
OT  - Rheumatoid arthritis
OT  - Subacute cutaneous lupus erythematosus
OT  - Systemic lupus erythematosus
EDAT- 2017/03/10 06:00
MHDA- 2017/03/10 06:01
PMCR- 2016/04/23
CRDT- 2017/03/10 06:00
PHST- 2016/01/21 00:00 [received]
PHST- 2016/04/15 00:00 [revised]
PHST- 2016/04/18 00:00 [accepted]
PHST- 2017/03/10 06:00 [entrez]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/03/10 06:01 [medline]
PHST- 2016/04/23 00:00 [pmc-release]
AID - S2090-1232(16)30021-2 [pii]
AID - 10.1016/j.jare.2016.04.001 [doi]
PST - ppublish
SO  - J Adv Res. 2016 Sep;7(5):719-726. doi: 10.1016/j.jare.2016.04.001. Epub 2016 Apr 
      23.