PMID- 28275781
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20181202
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 8
IP  - 4
DP  - 2017 Apr 19
TI  - Aqueous extracts from asparagus stems prevent memory impairments in 
      scopolamine-treated mice.
PG  - 1460-1467
LID - 10.1039/c7fo00028f [doi]
AB  - Aqueous extracts from Asparagus officinalis L. stems (AEAS) are rich in 
      polysaccharides, gamma-amino butyric acid (GABA), and steroidal saponin. This 
      study was designed to investigate the effects of AEAS on learning, memory, and 
      acetylcholinesterase-related activity in a scopolamine-induced model of amnesia. 
      Sixty ICR mice were randomly divided into 6 groups (n = 10) including the control 
      group (CT), scopolamine group (SC), donepezil group (DON), low, medium, and high 
      dose groups of AEAS (LS, MS, HS; 1.6 mL kg(-1), 8 mL kg(-1), 16 mL kg(-1)). The 
      results showed that 8 mL kg(-1) of AEAS used in this study significantly reversed 
      scopolamine-induced cognitive impairments in mice in the novel object recognition 
      test (P < 0.05) and the Y-maze test (P < 0.05), and also improved the latency to 
      escape in the Morris water maze test (P < 0.05). Moreover, it significantly 
      increased acetylcholine and inhibited acetylcholinesterase activity in the 
      hippocampus, which was directly related to the reduction in learning and memory 
      impairments. It also reversed scopolamine-induced reduction in the hippocampal 
      brain-derived neurotrophic factor (BDNF) and the cAMP response element-binding 
      protein (CREB) mRNA expression. AEAS protected against scopolamine-induced memory 
      deficits. In conclusion, AEAS protected learning and memory function in mice by 
      enhancing the activity of the cholinergic nervous system, and increasing BDNF and 
      CREB expression. This suggests that AEAS has the potential to prevent cognitive 
      impairments in age-related diseases, such as Alzheimer's disease.
FAU - Sui, Zifang
AU  - Sui Z
AD  - The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of 
      Education, School of Biotechnology, Jiangnan University, Wuxi214122, China.
FAU - Qi, Ce
AU  - Qi C
FAU - Huang, Yunxiang
AU  - Huang Y
FAU - Ma, Shufeng
AU  - Ma S
FAU - Wang, Xinguo
AU  - Wang X
FAU - Le, Guowei
AU  - Le G
FAU - Sun, Jin
AU  - Sun J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Plant Extracts)
RN  - DL48G20X8X (Scopolamine)
SB  - IM
MH  - Amnesia/chemically induced/*drug therapy/metabolism/psychology
MH  - Animals
MH  - Asparagus Plant/*chemistry
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/genetics/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Humans
MH  - Male
MH  - Memory/*drug effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Plant Extracts/*administration & dosage
MH  - Scopolamine/*administration & dosage
EDAT- 2017/03/10 06:00
MHDA- 2017/07/18 06:00
CRDT- 2017/03/10 06:00
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
PHST- 2017/03/10 06:00 [entrez]
AID - 10.1039/c7fo00028f [doi]
PST - ppublish
SO  - Food Funct. 2017 Apr 19;8(4):1460-1467. doi: 10.1039/c7fo00028f.