PMID- 28275883
OWN - NLM
STAT- MEDLINE
DCOM- 20180713
LR  - 20181113
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Nov
TI  - Elevated Plasma Homocysteine Level Increased the Risk of Early Renal Impairment 
      in Acute Ischemic Stroke Patients.
PG  - 1399-1405
LID - 10.1007/s10571-017-0470-8 [doi]
AB  - Renal insufficiency is associated with the prognosis of acute ischemic stroke 
      (AIS) and homocysteine (Hcy) levels. This study investigated the association 
      between plasma Hcy levels and renal insufficiency in patients with AIS. A total 
      of 987 patients with AIS who had been treated at the First People's Hospital of 
      Foshan between 2011 and 2014 were retrospectively studied. Based on their 
      cystatin C (Cys C) levels, the patients were divided into the normal renal 
      function group (Cys C </= 1.25 mg/L) or the renal impairment group (Cys 
      C > 1.25 mg/L). Multivariate regression analysis was applied to reveal the 
      association between hyperhomocysteinemia (HHcy) and renal impairment. The renal 
      impairment group showed more advanced age of onset, higher percentage of prior 
      stroke and hypertension, higher baseline National Institute of Health Stroke 
      Scale score, lower high-density lipoprotein cholesterol levels, and higher Hcy 
      levels compared with the normal renal function group. A multivariate analysis 
      revealed a relationship between early renal impairment and Hcy levels: an 
      increase of Hcy by 1 mumol/L was associated with an increase of 12-18% of the risk 
      of renal impairment among patients with AIS and HHcy. Patients with AIS and HHcy 
      had a 2.42-3.51 fold increase of the risk of renal impairment compared with 
      patients with normal Hcy level (P < 0.001). In conclusion, patients with stroke 
      and HHcy could be more prone to renal impairment.
FAU - Chen, Jingjuan
AU  - Chen J
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Li, Guode
AU  - Li G
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Xu, Zuohang
AU  - Xu Z
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Zhang, Chengguo
AU  - Zhang C
AD  - First People's Hospital of Foshan, Foshan, 528000, China. zcguo@fsyyy.com.
FAU - Wang, Yukai
AU  - Wang Y
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Xie, Haiqun
AU  - Xie H
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Shao, Yan
AU  - Shao Y
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Peng, Lingmei
AU  - Peng L
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Lu, Jiancong
AU  - Lu J
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
FAU - Yuan, Dahua
AU  - Yuan D
AD  - First People's Hospital of Foshan, Foshan, 528000, China.
LA  - eng
PT  - Journal Article
DEP - 20170308
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Biomarkers)
RN  - 0 (CST3 protein, human)
RN  - 0 (Cystatin C)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/diagnosis/epidemiology
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cystatin C/*blood
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/diagnosis
MH  - Kidney Diseases/*blood/diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stroke/*blood/diagnosis/epidemiology
OTO - NOTNLM
OT  - Cystatin C
OT  - Glomerular filtration rate
OT  - Homocysteine
OT  - Renal insufficiency
OT  - Stroke
EDAT- 2017/03/10 06:00
MHDA- 2018/07/14 06:00
CRDT- 2017/03/10 06:00
PHST- 2016/08/24 00:00 [received]
PHST- 2017/01/31 00:00 [accepted]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2018/07/14 06:00 [medline]
PHST- 2017/03/10 06:00 [entrez]
AID - 10.1007/s10571-017-0470-8 [pii]
AID - 10.1007/s10571-017-0470-8 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2017 Nov;37(8):1399-1405. doi: 10.1007/s10571-017-0470-8. 
      Epub 2017 Mar 8.