PMID- 28276512
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20191210
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
DP  - 2017 Mar 9
TI  - The efficacy and safety of SGLT2 inhibitors for adjunctive treatment of type 1 
      diabetes: a systematic review and meta-analysis.
PG  - 44128
LID - 10.1038/srep44128 [doi]
LID - 44128
AB  - To assess the efficacy and safety of the SGLT-2 inhibitors as adjunct therapy to 
      insulin in T1DM, clinical trials indexed in PubMed, Cochrane Library, EMbase from 
      inception through April 5, 2016. A meta-analysis was conducted on trials of 
      SGLT-2 inhibitors in patients with T1DM on insulin therapy using RevMan 5.3 
      software. Of the 371 articles identified, ten met eligibility criteria. Seven 
      clinical trials including four randomized controlled trials and 581 patients were 
      included. Compared with the control group, SGLT-2 inhibitors group had 
      significantly reduced fasting plasma glucose by 0.69 mmol/L [1.32; 0.07], 
      glycosylated hemoglobin A1C by 0.37% [0.54; 0.20], body weight by 2.54 kg [3.48; 
      1.60] and total daily insulin dose by 6.22 IU [8.04; 4.40]. The total incidence 
      of adverse events (AEs), hypoglycemia, and genital and urinary infections were 
      also similar to placebo, while an increased incidence of diabetic ketoacidosis 
      (DKA) (n = 16) was seen in SGLT-2 inhibitors group. The present study 
      demonstrates that SGLT-2 inhibitors are effective as adjunct therapy to insulin 
      in T1DM, heralding improved glycemic control, reduced body weight and total daily 
      insulin dose without an increase in total AEs, hypoglycemia, or genital and 
      urinary infections. However, the risk of DKA should be carefully monitored in 
      future clinical trials.
FAU - Chen, Jiao
AU  - Chen J
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical College, 
      Luzhou, Sichuan 646000, China.
FAU - Fan, Fang
AU  - Fan F
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical College, 
      Luzhou, Sichuan 646000, China.
FAU - Wang, J Y
AU  - Wang JY
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical College, 
      Luzhou, Sichuan 646000, China.
FAU - Long, Yang
AU  - Long Y
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical College, 
      Luzhou, Sichuan 646000, China.
FAU - Gao, C L
AU  - Gao CL
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical College, 
      Luzhou, Sichuan 646000, China.
FAU - Stanton, R C
AU  - Stanton RC
AD  - Joslin Diabetes Center, Boston, MA, USA.
AD  - Beth Israel Deaconess Medical Center, Boston, MA, Boston, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Xu, Yong
AU  - Xu Y
AD  - Department of Endocrinology, Affiliated Hospital of Southwest Medical College, 
      Luzhou, Sichuan 646000, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20170309
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (SLC5A2 protein, human)
RN  - 0 (Sodium-Glucose Transporter 2)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
SB  - IM
MH  - Diabetes Mellitus, Type 1/*drug therapy/metabolism/pathology
MH  - Humans
MH  - Hypoglycemia/chemically induced/metabolism
MH  - Hypoglycemic Agents/adverse effects/*therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
MH  - Sodium-Glucose Transporter 2
MH  - *Sodium-Glucose Transporter 2 Inhibitors
MH  - Urinary Tract Infections/chemically induced/metabolism
PMC - PMC5343472
COIS- The authors declare no competing financial interests.
EDAT- 2017/03/10 06:00
MHDA- 2018/11/09 06:00
PMCR- 2017/03/09
CRDT- 2017/03/10 06:00
PHST- 2016/08/03 00:00 [received]
PHST- 2017/02/03 00:00 [accepted]
PHST- 2017/03/10 06:00 [entrez]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2017/03/09 00:00 [pmc-release]
AID - srep44128 [pii]
AID - 10.1038/srep44128 [doi]
PST - epublish
SO  - Sci Rep. 2017 Mar 9;7:44128. doi: 10.1038/srep44128.