PMID- 28276824
OWN - NLM
STAT- MEDLINE
DCOM- 20171005
LR  - 20171005
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 52
IP  - 6-7
DP  - 2017 Jun-Jul
TI  - Clinical profile and treatment outcome of chronic pancreatitis in children: a 
      long-term follow-up study of 156 cases.
PG  - 773-778
LID - 10.1080/00365521.2017.1295465 [doi]
AB  - AIM: There is a paucity of literature in pediatric chronic pancreatitis (CP) and 
      most information is derived from adult literature. We, therefore, analyzed our 
      experience of CP to look for clinical profile and long-term outcome. METHODS: 
      From January 2003 to December 2015, 156 consecutive children (</=18 years) 
      diagnosed as CP were included. Their clinical profile, management, and follow-up 
      data were retrieved. Genetic markers (PRSS1, SPINK1, and CFTR) were studied in 40 
      idiopathic cases. RESULTS: The median age of the patients was 13 [inter-quartile 
      range (IQR): 10-14] years (93 males) and 134 (86%) were idiopathic. Genetic 
      mutations were found in 22/40 (55%) idiopathic cases. All but two presented with 
      pain abdomen (episodic pain in 93.6%) and symptom duration was 12 (IQR: 6-24) 
      months. There were two subsets; calcific (CCP) 68 (43.5%) and non-calcific (NCCP) 
      88 (56.5%). In CCP group, significantly more children had Cambridge grade 5 
      magnetic resonance cholangiopancreatography changes, low weight Z-score, and had 
      continuous pain more compared to NCCP group. Over a median follow-up of 23 (IQR: 
      8-45.5) months, more children in CCP group had complications. Endoscopic therapy 
      (done for persistent pain in 40) relieved pain in 52.5% of cases while medical 
      therapy did so in 36% of cases. CONCLUSION: Pediatric CP in Asia presents with 
      episodic pain and genetic predisposition seems to be a major cause. There are two 
      subsets; CCP and NCCP with former showing marked imaging changes, more often 
      associated with malnutrition and complications. Endoscopic therapy for pain 
      relief gives modest benefit but medical therapy is not encouraging.
FAU - Poddar, Ujjal
AU  - Poddar U
AD  - a Department of Pediatric Gastroenterology , Sanjay Gandhi Postgraduate Institute 
      of Medical Sciences , Lucknow , India.
FAU - Yachha, Surender Kumar
AU  - Yachha SK
AD  - a Department of Pediatric Gastroenterology , Sanjay Gandhi Postgraduate Institute 
      of Medical Sciences , Lucknow , India.
FAU - Borkar, Vibhor
AU  - Borkar V
AD  - a Department of Pediatric Gastroenterology , Sanjay Gandhi Postgraduate Institute 
      of Medical Sciences , Lucknow , India.
FAU - Srivastava, Anshu
AU  - Srivastava A
AD  - a Department of Pediatric Gastroenterology , Sanjay Gandhi Postgraduate Institute 
      of Medical Sciences , Lucknow , India.
FAU - Saraswat, Vivek A
AU  - Saraswat VA
AD  - b Department of Gastroenterology , Sanjay Gandhi Postgraduate Institute of 
      Medical Sciences , Lucknow , India.
LA  - eng
PT  - Journal Article
DEP - 20170301
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Abdominal Pain/etiology
MH  - Adolescent
MH  - Biomarkers, Tumor/genetics
MH  - Calcinosis
MH  - Child
MH  - Cholangiopancreatography, Endoscopic Retrograde
MH  - Cholangiopancreatography, Magnetic Resonance
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - India
MH  - Logistic Models
MH  - Male
MH  - Malnutrition
MH  - Mutation
MH  - Pancreatitis, Chronic/*diagnostic imaging/*genetics/*surgery
MH  - Recurrence
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Idiopathic
OT  - chronic-calcific
OT  - endoscopic therapy
OT  - genetic mutations
OT  - malnutrition
EDAT- 2017/03/10 06:00
MHDA- 2017/10/06 06:00
CRDT- 2017/03/10 06:00
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/10/06 06:00 [medline]
PHST- 2017/03/10 06:00 [entrez]
AID - 10.1080/00365521.2017.1295465 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2017 Jun-Jul;52(6-7):773-778. doi: 
      10.1080/00365521.2017.1295465. Epub 2017 Mar 1.