PMID- 28277116
OWN - NLM
STAT- MEDLINE
DCOM- 20180301
LR  - 20180816
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 33
IP  - 6
DP  - 2017 Jun
TI  - Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling 
      pathway.
PG  - 485-489
LID - 10.1080/09513590.2017.1295439 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth 
      factors family. Recent studies indicated that the level of BDNF in follicular 
      fluid is a marker for oocyte quality and infertility. Here, we intend to further 
      investigate the function of BDNF and its signaling pathway in the regulation of 
      endometrial cells proliferation. We found that BDNF is a critical growth factor 
      in endometrial cells. Activation of signal transducer and activator of 
      transcription 3 signaling pathway is required for BNDF-regulated endometrial cell 
      proliferation. Furthermore, BDNF is an effector of estrogen in endometrial cells. 
      Finally, we investigated the different role of Val66Met, a single-nucleotide 
      polymorphism of the BDNF gene, in regulating endometrial cells proliferation. The 
      results showed that BDNF(V66M) polymorphism is a loss-of-function polymorphism in 
      the regulation of endometrial cells growth. Given the correlation between 
      endometriosis and infertility, it is important to understand the role of BDNF in 
      regulating endometrial cells proliferation and to develop new therapeutic 
      strategies for the treatment of endometriosis-related infertility.
FAU - Dong, Fangzheng
AU  - Dong F
AD  - a Department of Pharmacology , Boston University School of Medicine , Boston , MA 
      , USA.
FAU - Zhang, Qiyao
AU  - Zhang Q
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
FAU - Kong, Wei
AU  - Kong W
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
FAU - Chen, Jun
AU  - Chen J
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
FAU - Ma, Junlan
AU  - Ma J
AD  - c Department of Microbiology , University of Iowa , Iowa City , IA , USA.
FAU - Wang, Li
AU  - Wang L
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
FAU - Wang, Yanian
AU  - Wang Y
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
FAU - Liu, Yan
AU  - Liu Y
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
FAU - Li, Yan
AU  - Li Y
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
FAU - Wen, Ji
AU  - Wen J
AD  - b Department of Reproduction , The 2nd Affiliate Hospital, Shandong University of 
      TCM , Jinan , China , and.
LA  - eng
PT  - Journal Article
DEP - 20170302
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogens)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Line, Tumor
MH  - *Cell Proliferation
MH  - Endometrium/*physiology
MH  - Estrogens/physiology
MH  - Female
MH  - Humans
MH  - Loss of Function Mutation
MH  - Polymorphism, Genetic
MH  - STAT3 Transcription Factor/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - endometrial cells
OT  - endometriosis Val66Met
OT  - signal transducer and activator of transcription 3
EDAT- 2017/03/10 06:00
MHDA- 2018/03/02 06:00
CRDT- 2017/03/10 06:00
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2018/03/02 06:00 [medline]
PHST- 2017/03/10 06:00 [entrez]
AID - 10.1080/09513590.2017.1295439 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2017 Jun;33(6):485-489. doi: 10.1080/09513590.2017.1295439. 
      Epub 2017 Mar 2.