PMID- 28279591
OWN - NLM
STAT- MEDLINE
DCOM- 20170915
LR  - 20180302
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 38
IP  - 4
DP  - 2017 Apr
TI  - HLA-G: At the Interface of Maternal-Fetal Tolerance.
PG  - 272-286
LID - S1471-4906(17)30023-6 [pii]
LID - 10.1016/j.it.2017.01.009 [doi]
AB  - During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the 
      uterine mucosa without being rejected by the maternal immune system. Several 
      mechanisms were initially proposed by Peter Medawar half a century ago to explain 
      this apparent violation of the laws of transplantation. Then, three decades ago, 
      an unusual human leukocyte antigen (HLA) molecule was identified: HLA-G. Uniquely 
      expressed in EVT, HLA-G has since become the center of the present understanding 
      of fetus-induced immune tolerance. Despite slow progress in the field, the last 
      few years have seen an explosion in our knowledge of HLA-G biology. Here, we 
      critically review new insights into the mechanisms controlling the expression and 
      function of HLA-G at the maternal-fetal interface, and discuss their relevance 
      for fetal tolerance.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Ferreira, Leonardo M R
AU  - Ferreira LMR
AD  - Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, 
      MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, 
      Cambridge, MA 02138, USA.
FAU - Meissner, Torsten B
AU  - Meissner TB
AD  - Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, 
      MA 02138, USA.
FAU - Tilburgs, Tamara
AU  - Tilburgs T
AD  - Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, 
      MA 02138, USA.
FAU - Strominger, Jack L
AU  - Strominger JL
AD  - Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, 
      MA 02138, USA. Electronic address: jlstrom@fas.harvard.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170306
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (HLA-G Antigens)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Animals
MH  - Female
MH  - HLA-G Antigens/immunology/*metabolism
MH  - Histocompatibility
MH  - Humans
MH  - Isoantigens/immunology
MH  - *Maternal-Fetal Relations
MH  - Pregnancy/*immunology
MH  - *Transplantation Tolerance
MH  - Trophoblasts/*immunology
EDAT- 2017/03/11 06:00
MHDA- 2017/09/16 06:00
CRDT- 2017/03/11 06:00
PHST- 2016/11/17 00:00 [received]
PHST- 2017/01/23 00:00 [revised]
PHST- 2017/01/27 00:00 [accepted]
PHST- 2017/03/11 06:00 [pubmed]
PHST- 2017/09/16 06:00 [medline]
PHST- 2017/03/11 06:00 [entrez]
AID - S1471-4906(17)30023-6 [pii]
AID - 10.1016/j.it.2017.01.009 [doi]
PST - ppublish
SO  - Trends Immunol. 2017 Apr;38(4):272-286. doi: 10.1016/j.it.2017.01.009. Epub 2017 
      Mar 6.