PMID- 28280960
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20181113
IS  - 1432-2013 (Electronic)
IS  - 0031-6768 (Print)
IS  - 0031-6768 (Linking)
VI  - 469
IP  - 5-6
DP  - 2017 Jun
TI  - Neurobiology of local and intercellular BDNF signaling.
PG  - 593-610
LID - 10.1007/s00424-017-1964-4 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family 
      of secreted proteins. Signaling cascades induced by BDNF and its receptor, the 
      receptor tyrosine kinase TrkB, link neuronal growth and differentiation with 
      synaptic plasticity. For this reason, interference with BDNF signaling has 
      emerged as a promising strategy for potential treatments in psychiatric and 
      neurological disorders. In many brain circuits, synaptically released BDNF is 
      essential for structural and functional long-term potentiation, two prototypical 
      cellular models of learning and memory formation. Recent studies have revealed an 
      unexpected complexity in the synaptic communication of mature BDNF and its 
      precursor proBDNF, not only between local pre- and postsynaptic neuronal targets 
      but also with participation of glial cells. Here, we consider recent findings on 
      local actions of the BDNF family of ligands at the synapse and discuss converging 
      lines of evidence which emerge from per se conflicting results.
FAU - Sasi, Manju
AU  - Sasi M
AD  - Institute of Clinical Neurobiology, University Hospital, University of Wurzburg, 
      97078, Wurzburg, Germany.
FAU - Vignoli, Beatrice
AU  - Vignoli B
AD  - Centre for Integrative Biology (CIBIO), University of Trento, 38123, Povo, TN, 
      Italy.
FAU - Canossa, Marco
AU  - Canossa M
AD  - Centre for Integrative Biology (CIBIO), University of Trento, 38123, Povo, TN, 
      Italy.
AD  - European Brain Research Institute (EBRI) "Rita Levi-Montalcini", 00143, Rome, 
      Italy.
FAU - Blum, Robert
AU  - Blum R
AUID- ORCID: 0000-0002-5270-3854
AD  - Institute of Clinical Neurobiology, University Hospital, University of Wurzburg, 
      97078, Wurzburg, Germany. Blum_R@UKW.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170309
PL  - Germany
TA  - Pflugers Arch
JT  - Pflugers Archiv : European journal of physiology
JID - 0154720
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
EIN - Pflugers Arch. 2017 Jun;469(5-6):611. PMID: 28361353
MH  - Animals
MH  - Anxiety Disorders/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Humans
MH  - Long-Term Potentiation
MH  - Receptor, trkB/metabolism
MH  - Synapses/*metabolism/physiology
MH  - Synaptic Transmission
PMC - PMC5438432
OTO - NOTNLM
OT  - Anxiety disorders
OT  - BDNF
OT  - Long-term potentiation
OT  - Signaling
OT  - Synaptic localization
OT  - Synaptic plasticity
OT  - TrkB
COIS- The authors declare that they have no competing financial interest.
EDAT- 2017/03/11 06:00
MHDA- 2018/03/06 06:00
PMCR- 2017/03/09
CRDT- 2017/03/11 06:00
PHST- 2017/01/14 00:00 [received]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/02/27 00:00 [revised]
PHST- 2017/03/11 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/03/11 06:00 [entrez]
PHST- 2017/03/09 00:00 [pmc-release]
AID - 10.1007/s00424-017-1964-4 [pii]
AID - 1964 [pii]
AID - 10.1007/s00424-017-1964-4 [doi]
PST - ppublish
SO  - Pflugers Arch. 2017 Jun;469(5-6):593-610. doi: 10.1007/s00424-017-1964-4. Epub 
      2017 Mar 9.