PMID- 28281675
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
DP  - 2017 Mar 10
TI  - Excretion rates of 1,5-anhydro-D-glucitol, uric acid and microalbuminuria as 
      glycemic control indexes in patients with type 2 diabetes.
PG  - 44291
LID - 10.1038/srep44291 [doi]
LID - 44291
AB  - 1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into 
      the urine with increasing glucosuria. In the present retrospective study we 
      analyzed whether these factors could be used as indicators for type 2 diabetes 
      mellitus (T2DM) glucose control in 6,766 (T2DM) patients. There were 3,988 cases 
      (58.9%) with HbA1c </= 6.5%, 853 cases (12.61%) with HbA1c levels ranging from 6.5% 
      to 7% and 1,925 cases (28.5%) with HbA1c > 7%. HbA1c percentages were correlated 
      with age, MA and 1,5-AG serum concentrations (P < 0.001). The serum uric acid 
      concentration (P < 0.001) was significantly lower in elevated MA (P < 0.001) and 
      24-hour urinary protein (P = 0.024) patients. Hb1Ac percentages (P < 0.001) were 
      significantly enhanced in patients with 1,5-AG serum concentrations </=10 mg/L 
      compared to >10 mg/L. With a derived receiver operating characteristic (ROC) 
      curve, a 1,5-AG cut-off value of 11.55 mg/L for hyperglycemia could be diagnosed 
      with a specificity of 71.2 (69.7-72.6) and a sensitivity of 75.3 (73.6-76.9). The 
      serum 1,5-AG concentration is a marker for hyperglycemia and may be particularly 
      useful as an indicator for short-term glycemic excursions in order to improve 
      treatments in T2DM patients.
FAU - Ma, Cong
AU  - Ma C
AD  - Department of Endocrinology, Xuhui District Central Hospital, No. 966, Huaihai 
      Zhong Road, Shanghai 200031, China.
FAU - Sheng, Junqin
AU  - Sheng J
AD  - Department of Nephrology, Xuhui District Central Hospital, No. 966, Huaihai Zhong 
      Road, Shanghai 200031, China.
FAU - Liu, Zhiwen
AU  - Liu Z
AD  - Department of Endocrinology, Xuhui District Central Hospital, No. 966, Huaihai 
      Zhong Road, Shanghai 200031, China.
FAU - Guo, Minghao
AU  - Guo M
AD  - Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai JiaoTong 
      University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, China.
LA  - eng
PT  - Journal Article
DEP - 20170310
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 268B43MJ25 (Uric Acid)
RN  - 54BB3B7XMZ (1,5-anhydroglucitol)
RN  - 9G2MP84A8W (Deoxyglucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/*blood
MH  - Blood Glucose/*metabolism
MH  - Deoxyglucose/*blood
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis
MH  - Female
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Uric Acid/*blood
MH  - Young Adult
PMC - PMC5345080
COIS- The authors declare no competing financial interests.
EDAT- 2017/03/11 06:00
MHDA- 2018/11/27 06:00
PMCR- 2017/03/10
CRDT- 2017/03/11 06:00
PHST- 2016/11/18 00:00 [received]
PHST- 2017/02/06 00:00 [accepted]
PHST- 2017/03/11 06:00 [entrez]
PHST- 2017/03/11 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2017/03/10 00:00 [pmc-release]
AID - srep44291 [pii]
AID - 10.1038/srep44291 [doi]
PST - epublish
SO  - Sci Rep. 2017 Mar 10;7:44291. doi: 10.1038/srep44291.