PMID- 28282939
OWN - NLM
STAT- MEDLINE
DCOM- 20170731
LR  - 20181202
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 14
IP  - 3
DP  - 2017 Mar 9
TI  - Oral Health Status of Patients with Lysosomal Storage Diseases in Poland.
LID - 10.3390/ijerph14030281 [doi]
LID - 281
AB  - Patients with lysosomal storage diseases (LSDs) suffer from physical and mental 
      disabilities, which together with poor access to professional care may lead to 
      impaired oral health. This cross-sectional case-control study characterized the 
      status of oral health in patients with LSDs in Poland. Thirty-six children and 
      young adults with various forms of LSDs were examined. The data were compared 
      with those from age- and sex-matched healthy controls. Exemplary cases were 
      presented to highlight typical problems in oral care associated with LSDs. When 
      possible, saliva was collected and analyzed for total protein, inflammatory 
      mediators, and antioxidant status. Generally, patients with LSDs had 
      significantly higher prevalence of caries, inferior gingival status, and 
      inadequate oral hygiene. The severity of oral health impairment in 
      mucopolysaccaridoses, the most common LSD in Poland, was similar to that seen in 
      patients with mannosidoses or Pompe disease. Saliva could be collected only from 
      few less handicapped patients. In MPS, it did not appear to differ significantly 
      from the controls, but in patients with Pompe disease it contained lower 
      concentrations of vascular endothelial growth factor (VEGF) and monocyte 
      chemoattractant protein-1 (MCP-1), but higher levels of tumor necrosis factor 
      receptors 1 and 2 (TNF-R1, TNF-R2) and myeloperoxidase (MPO). In conclusion, 
      Polish patients with LSDs have an inadequate level of oral hygiene and 
      substantially deteriorated oral health.
FAU - Drazewski, Damian
AU  - Drazewski D
AD  - Department of Conservative Dentistry and Periodontology, Poznan University of 
      Medical Sciences, 60-812 Poznan, Poland. damian.stom@gmail.com.
FAU - Grzymislawska, Malgorzata
AU  - Grzymislawska M
AD  - Department of Anatomy, Poznan University of Medical Sciences, 61-781 Poznan, 
      Poland. malgorzatagrzymislawska@ump.edu.pl.
FAU - Korybalska, Katarzyna
AU  - Korybalska K
AD  - Department of Pathophysiology, Poznan University of Medical Sciences, 60-806 
      Poznan, Poland. koryb@amp.edu.pl.
FAU - Czepulis, Natasza
AU  - Czepulis N
AD  - Department of Pathophysiology, Poznan University of Medical Sciences, 60-806 
      Poznan, Poland. czepulis@ump.edu.pl.
FAU - Grzymislawski, Marian
AU  - Grzymislawski M
AD  - Department of Metabolic Disease, Nutrition and Internal Medicine, Poznan 
      University of Medical Sciences, 60-355 Poznan, Poland. mariangrzym@ump.edu.pl.
FAU - Witowski, Janusz
AU  - Witowski J
AD  - Department of Pathophysiology, Poznan University of Medical Sciences, 60-806 
      Poznan, Poland. jwitow@ump.edu.pl.
FAU - Surdacka, Anna
AU  - Surdacka A
AD  - Department of Conservative Dentistry and Periodontology, Poznan University of 
      Medical Sciences, 60-812 Poznan, Poland. annasurd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170309
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Cross-Sectional Studies
MH  - Dental Caries/*etiology
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Lysosomal Storage Diseases/*complications/*epidemiology
MH  - Male
MH  - *Oral Health
MH  - Oral Hygiene
MH  - Poland/epidemiology
MH  - Prevalence
MH  - Saliva/*chemistry
MH  - Young Adult
PMC - PMC5369117
OTO - NOTNLM
OT  - developmental disabilities
OT  - lysosomal storage disease
OT  - oral health
OT  - saliva
EDAT- 2017/03/12 06:00
MHDA- 2017/08/02 06:00
PMCR- 2017/03/01
CRDT- 2017/03/12 06:00
PHST- 2017/01/16 00:00 [received]
PHST- 2017/02/20 00:00 [revised]
PHST- 2017/03/02 00:00 [accepted]
PHST- 2017/03/12 06:00 [entrez]
PHST- 2017/03/12 06:00 [pubmed]
PHST- 2017/08/02 06:00 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - ijerph14030281 [pii]
AID - ijerph-14-00281 [pii]
AID - 10.3390/ijerph14030281 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2017 Mar 9;14(3):281. doi: 
      10.3390/ijerph14030281.