PMID- 28284898
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20171205
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1663
DP  - 2017 May 15
TI  - Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like 
      behaviors induced by an animal model of depression.
PG  - 29-37
LID - S0006-8993(17)30082-3 [pii]
LID - 10.1016/j.brainres.2017.02.020 [doi]
AB  - Major depressive disorder (MDD) is one of the most common psychiatric disorder, 
      but the underlying mechanisms are largely unknown. Increasing evidence shows that 
      brain-derived neurotrophic factor (BDNF) plays an important role in the 
      structural plasticity induced by depression. Considering the opposite effects of 
      BDNF and its precursor proBDNF on neural plasticity, we hypothesized that the 
      balance of BDNF and proBDNF plays a critical role in chronic unpredicted mild 
      stress (CUMS)-induced depressive-like behaviors and structural plasticity in the 
      rodent hippocampus. The aims of this study were to compare the functions of BDNF 
      and proBDNF in the CUMS-induced depressive-like behaviors, and determine the 
      effects of BDNF and proBDNF on expressions of kalirin-7, postsynaptic density 
      protein 95 (PSD95) and NMDA receptor subunit NR2B in the hippocampus of stressed 
      and naive control rats, respectively. Our results showed that CUMS induced 
      depressive-like behaviors, caused a decrease in the ratio of BDNF/proBDNF in the 
      hippocampus and resulted in a reduction in spine density in hippocampal CA1 
      pyramidal neurons; these alterations were accompanied by a decrease in the levels 
      of kalirin-7, PSD95 and NR2B in the hippocampus. Injection of exogenous BDNF into 
      the CA1 area of stressed rats reversed CUMS-induced depressive-like behaviors and 
      prevented CUMS-induced spine loss and decrease in kalirin-7, NR2B and PSD95 
      levels. In contrast, injection of exogenous proBDNF into the CA1 region of naive 
      rats caused depressive-like behavior and an accompanying decrease in both spine 
      density and the levels of kalirin-7, NR2B and PSD95. Taken together, our results 
      suggest that the ratio of BDNF to proBDNF in the hippocampus plays a key role in 
      CUMS-induced depressive-like behaviors and alterations of dendritic spines in 
      hippocampal CA1 pyramidal neurons. Kalirin-7 may play an important role during 
      this process.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Qiao, Hui
AU  - Qiao H
AD  - College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi Province 
      710062, PR China.
FAU - An, Shu-Cheng
AU  - An SC
AD  - College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi Province 
      710062, PR China. Electronic address: shuchengan@snnu.edu.cn.
FAU - Xu, Chang
AU  - Xu C
AD  - College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi Province 
      710062, PR China.
FAU - Ma, Xin-Ming
AU  - Ma XM
AD  - College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi Province 
      710062, PR China; University of Connecticut Health Center, Department of 
      Neuroscience, Farmington, CT 06030, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170308
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism/physiology
MH  - Dendritic Spines/metabolism/*physiology
MH  - Depression/*metabolism
MH  - Depressive Disorder, Major/metabolism
MH  - Disease Models, Animal
MH  - Hippocampus/metabolism
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological
OTO - NOTNLM
OT  - BDNF
OT  - Dendritic spine
OT  - Depression
OT  - Kalirin
OT  - Stress
OT  - proBDNF
EDAT- 2017/03/13 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/03/13 06:00
PHST- 2016/09/13 00:00 [received]
PHST- 2017/02/14 00:00 [revised]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/03/13 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/03/13 06:00 [entrez]
AID - S0006-8993(17)30082-3 [pii]
AID - 10.1016/j.brainres.2017.02.020 [doi]
PST - ppublish
SO  - Brain Res. 2017 May 15;1663:29-37. doi: 10.1016/j.brainres.2017.02.020. Epub 2017 
      Mar 8.