PMID- 28284951
OWN - NLM
STAT- MEDLINE
DCOM- 20180307
LR  - 20180322
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 326
DP  - 2017 May 30
TI  - Hippocampal BDNF overexpression or microR124a silencing reduces anxiety- and 
      autism-like behaviors in rats.
PG  - 281-290
LID - S0166-4328(16)31330-4 [pii]
LID - 10.1016/j.bbr.2017.03.010 [doi]
AB  - MicroRNA124a (miR124a) has emerged recently as a key player for multiple 
      neuropsychiatric disorders including depression, anxiety, alcoholism, and cocaine 
      addiction. Although we have previously reported that miR124a and its target the 
      brain-derived neutrophic factor (BDNF) play an important role in autism-like 
      behaviors, the molecular and behavioral dysfunctions remain unknown. The aim of 
      this study was to understand the effects of sustained decreases in miR124a and 
      increases of BDNF in the dentate gyrus (DG) on neonatal isolation-induced 
      anxiety-and autism like behaviors in rats. Here we report that 
      lentiviral-mediated silencing of miR124a in the adult DG attenuated neonatal 
      isolation-induced anxiety-like behavior in the elevated plus maze (EPM) and 
      open-field (OF) tests. Also, miR124a silencing decreased autism-like phenotype in 
      the marble burying test (MBT), self-grooming (SG), and social interaction tests. 
      Pearson's correlations demonstrated that high levels of BDNF, a direct target of 
      miR124a, were negatively correlated with miR124a expression. Interestingly, 
      viral-mediated BDNF overexpression in the DG also reversed the neonatal 
      isolation-induced anxiety-and autism like phenotypes. Collectively, these 
      findings suggest that miR124a, through its target BDNF, may influence neonatal 
      isolation-induced anxiety-and autism like behaviors. In conclusion, these results 
      do support the hypothesis that miR124a in discrete hippocampal areas contributes 
      to anxiety- and autism-like behaviors and may be involved in the neuroadaptations 
      underlying the development of autism spectrum disorders as a persistent and 
      lasting condition, and therefore provide a clearer mechanistic framework for 
      understanding the physiopathology of such psychiatric illnesses.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Bahi, Amine
AU  - Bahi A
AD  - Department of Anatomy, Tawam Medical Campus, United Arab Emirates University, Al 
      Ain, United Arab Emirates. Electronic address: amine.bahi@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170308
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MIRN124 microRNA, rat)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Anxiety/*metabolism/*physiopathology
MH  - Autism Spectrum Disorder/*metabolism/*physiopathology
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dentate Gyrus/*metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Hippocampus/*metabolism
MH  - Male
MH  - MicroRNAs/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Social Behavior
OTO - NOTNLM
OT  - Anxiety
OT  - Autism spectrum disorders
OT  - BDNF
OT  - Elevated plus maze
OT  - Marble burying test
OT  - Open-field
OT  - Self-grooming
OT  - Social behavior
OT  - microRNA124a
EDAT- 2017/03/13 06:00
MHDA- 2018/03/08 06:00
CRDT- 2017/03/13 06:00
PHST- 2016/12/28 00:00 [received]
PHST- 2017/02/27 00:00 [revised]
PHST- 2017/03/04 00:00 [accepted]
PHST- 2017/03/13 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
PHST- 2017/03/13 06:00 [entrez]
AID - S0166-4328(16)31330-4 [pii]
AID - 10.1016/j.bbr.2017.03.010 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 May 30;326:281-290. doi: 10.1016/j.bbr.2017.03.010. Epub 
      2017 Mar 8.