PMID- 28285155
OWN - NLM
STAT- MEDLINE
DCOM- 20180219
LR  - 20181030
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 43
DP  - 2017 May
TI  - Grape powder consumption affects the expression of neurodegeneration-related 
      brain proteins in rats chronically fed a high-fructose-high-fat diet.
PG  - 132-140
LID - S0955-2863(16)30663-5 [pii]
LID - 10.1016/j.jnutbio.2017.02.013 [doi]
AB  - Abnormal glucose metabolism in the brain is recognized to be associated with 
      cognitive decline. Because grapes are rich in polyphenols that produce 
      antioxidative and blood sugar-lowering effects, we investigated how grape 
      consumption affects the expression and/or phosphorylation of 
      neurodegeneration-related brain proteins in aged rats fed a 
      high-fructose-high-fat (HFHF) diet. Wistar rats were maintained on the HFHF diet 
      from the age of 8 weeks to 66 weeks, and then on an HFHF diet containing either 
      3% or 6% grape powder as an intervention for 12 weeks. Western blotting was 
      performed to measure the expression/phosphorylation levels of several cortical 
      and hippocampal proteins, including amyloid precursor protein (APP), tau, 
      phosphatidylinositol-3-kinase (PI3K), extracellular signal-regulated kinase 
      (ERK), receptor for advanced glycation end products (RAGEs), erythroid 2-related 
      factor 2 (Nrf2) and brain-derived neurotrophic factor (BDNF). Inclusion of up to 
      6% grape powder in the diet markedly reduced RAGE expression and tau 
      hyperphosphorylation, but upregulated the expression of Nrf2 and BDNF, as well as 
      the phosphorylation of PI3K and ERK, in the brain tissues of aged rats fed the 
      HFHF diet. Thus, grape powder consumption produced beneficial effects in 
      HFHF-diet-fed rats, exhibiting the potential to ameliorate changes in 
      neurodegeneration-related proteins in the brain.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Liao, Hsiang
AU  - Liao H
AD  - School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing 
      Street, Taipei 11031, Taiwan.
FAU - Chou, Liang-Mao
AU  - Chou LM
AD  - School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing 
      Street, Taipei 11031, Taiwan.
FAU - Chien, Yi-Wen
AU  - Chien YW
AD  - School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing 
      Street, Taipei 11031, Taiwan.
FAU - Wu, Chi-Hao
AU  - Wu CH
AD  - School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing 
      Street, Taipei 11031, Taiwan.
FAU - Chang, Jung-Su
AU  - Chang JS
AD  - School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing 
      Street, Taipei 11031, Taiwan.
FAU - Lin, Ching-I
AU  - Lin CI
AD  - Department of Nutrition and Health Sciences, Kainan University, 1 Kainan Road, 
      Luzhu, Taoyuan City 33857, Taiwan.
FAU - Lin, Shyh-Hsiang
AU  - Lin SH
AD  - School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing 
      Street, Taipei 11031, Taiwan. Electronic address: lin5611@tmu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20170302
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Ager protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Mapt protein, rat)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Powders)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (tau Proteins)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Brain/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition Disorders/diet therapy/etiology
MH  - Diet, High-Fat/adverse effects
MH  - Dietary Supplements
MH  - Fructose/adverse effects
MH  - Hyperglycemia/diet therapy/*physiopathology
MH  - Male
MH  - NF-E2-Related Factor 2/metabolism
MH  - Neurodegenerative Diseases/metabolism
MH  - Powders/pharmacology
MH  - Rats, Wistar
MH  - Receptor for Advanced Glycation End Products/metabolism
MH  - Vitis/*chemistry
MH  - tau Proteins/metabolism
OTO - NOTNLM
OT  - AD
OT  - BDNF
OT  - Grape
OT  - High-fructose-high-fat
OT  - Nrf2
OT  - RAGE
EDAT- 2017/03/13 06:00
MHDA- 2018/02/20 06:00
CRDT- 2017/03/13 06:00
PHST- 2016/11/02 00:00 [received]
PHST- 2017/01/11 00:00 [revised]
PHST- 2017/02/08 00:00 [accepted]
PHST- 2017/03/13 06:00 [pubmed]
PHST- 2018/02/20 06:00 [medline]
PHST- 2017/03/13 06:00 [entrez]
AID - S0955-2863(16)30663-5 [pii]
AID - 10.1016/j.jnutbio.2017.02.013 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2017 May;43:132-140. doi: 10.1016/j.jnutbio.2017.02.013. Epub 
      2017 Mar 2.